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Information Journal Paper

Title

THE CORRELATION BETWEEN HBE-AG AND ALANINE AMINOTRANSFERASE LEVELS IN CHRONIC HEPATITIS B WITH PCR POSITIVE PATIENTS

Pages

  29-34

Keywords

ALTQ3

Abstract

 Background: HBV is estimated to have infected 350, millions people world wide and can induce a spectrum of acute and chronic liver diseases. Replication of virus and progress of diseases is dependant on presence of specific markers in blood. These markers include ALT levels, presence or absence of HBe antigen and degree of viremia i.e. HBV-DNA level in blood. It had been reported that there is a direct correlation between HBe Ag and ALT level. Our aim is study of this correlation till if it found correct HBe - antigen is taken as an ALTernate for determination of chronicity in chronic hepatitis B patients when we don't have PCR.Material and methods: In this retrospective study, 120 patients who were found to be HBs Ag positive were evalvated by testing HBs Ag, HBe Ab and ALT. If ALT was  abnormal (X≥2 Normal) that patient was tested for HBV - DNA. Patients were divided into two groups: Group A (HBe Ag positive) and Group B (HBe Ab positive).The Correlation between HBe Ag and ALT was evaluated. we evaluated this correlation a bout HBV - DNA positive patients also. Age was a demographic factor in this study. The data were analyzed by spss version 11.5, t-test and K2.Results: out of 120 patients, 78.3% were male. The mean age of the sample population was 32.5 years (Range 6-67). HBE - AG was positive in 19 cases (15.8%) patients with HBE - AG positive were younger and their mean ALT was also higher. HBE - AG+ patients have ALT=74. 32±23.23 and HBe - Ab+ patients have ALT= 30.42±8.69. (P=0.007 raised ALT and AST are likely to be positive for HBV-DNA. The combination of routine serology and biochemical tests may be considered as an ALTernative to HBV - DNA in evaluating the chronic HBV infection.

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    APA: Copy

    NOKHOUDIAN, Z., & ATAEI, B.. (2006). THE CORRELATION BETWEEN HBE-AG AND ALANINE AMINOTRANSFERASE LEVELS IN CHRONIC HEPATITIS B WITH PCR POSITIVE PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 11(32), 29-34. SID. https://sid.ir/paper/52892/en

    Vancouver: Copy

    NOKHOUDIAN Z., ATAEI B.. THE CORRELATION BETWEEN HBE-AG AND ALANINE AMINOTRANSFERASE LEVELS IN CHRONIC HEPATITIS B WITH PCR POSITIVE PATIENTS. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2006;11(32):29-34. Available from: https://sid.ir/paper/52892/en

    IEEE: Copy

    Z. NOKHOUDIAN, and B. ATAEI, “THE CORRELATION BETWEEN HBE-AG AND ALANINE AMINOTRANSFERASE LEVELS IN CHRONIC HEPATITIS B WITH PCR POSITIVE PATIENTS,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 11, no. 32, pp. 29–34, 2006, [Online]. Available: https://sid.ir/paper/52892/en

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