INVESTIGATION OF METALO -BETA- LACTAMASE AND DETERMINATION OF ANTIBIOTIC RESISTANCE TO CEFTAZIDIME AND IMIPENEM TO P.AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS IN EMAM KHOMEINE AND MARKAZE TEBI-KODAKAN HOSPITALS IN 1384

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SHAH CHERAGHI F.; NIKBIN V.A.S.

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2007 | Volume:12 | Issue:36 Page(s): 19-22

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Title

INVESTIGATION OF METALO -BETA- LACTAMASE AND DETERMINATION OF ANTIBIOTIC RESISTANCE TO CEFTAZIDIME AND IMIPENEM TO P.AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS IN EMAM KHOMEINE AND MARKAZE TEBI-KODAKAN HOSPITALS IN 1384

Author(s)

SHAH CHERAGHI F. | NIKBIN V.A.S. | Issue Writer Certificate

Keywords

METALO-BETA-LACTAMASEQ2

PSEUDOMONAS AERUGINOSAQ3

ANTIBIOTIC RESISTANCEQ2

Abstract

Background and objective: One of the mechanisms for carbapenem resistance in P.aeruginosa is production of metalo-betalactamases. carbapenem resistance among P.aeruginosa is becoming a critical therapeutic problem worldwide. Given the importance of Carbapenem-resistant p.aeruginosa strains as multidrug-resistant pathogens and our recognition of their presence in Tehran, we under took a study to investigate the outcomes of these strains and production of METALO-BETA-LACTAMASE in these bacteria.Material and methods: Antibiotic susceptibility testing of 350 P.aeruginosa isolated strains was performed as recommended by NCCLS using disk containing ceftazidime (CAZ), Ceftriaxone(CRO), cefotaxime (CTX), ceftizoxime(ZOX), piperacilin (PIP), piperacilin/tazobactam(PT), gentamicin(GM), amikacin (AN), imipenem (IMP), ciprofloxacin (CIP) (BBL).MICs for ceftazidime were determined by micro dilution method.For detection of MBLs we used double disk diffusion test. Results: In our study IMP was the most sensitive antibiotic (% 95) and ZOX was the most resistance to the p.aeruginosa strains. 43% isolates showed MIC>16mg/ml for ceftazidime (Emam Khomeine 64.2% and markaze tebi-kodakan 21.5%).Discussion: Our results showed that ANTIBIOTIC RESISTANCE to CAZ and IMP in P.aeruginosa is increasing. MBL -producing strains are of additional important from an infection-control perspective, because they may be responsible for horizontal transmission of the resistant genes conferring carbapenem resistance in other strains of P.aeruginosa or even in unrelated gram negative organisms. Care should be taken to use imipenem just in critical condition.

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بررسی میزان مقاومت دارویی، فعالیت بتالاکتاماز و تعیین سروتایپ های سویه های پسودوموناس آئروژینوزای جدا شده از بیماران سوختگی در بیمارستان سوانح و سوختگی توحید در سال 1380

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APA: Copy

SHAH CHERAGHI, F., & NIKBIN, V.A.S.. (2007). INVESTIGATION OF METALO -BETA- LACTAMASE AND DETERMINATION OF ANTIBIOTIC RESISTANCE TO CEFTAZIDIME AND IMIPENEM TO P.AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS IN EMAM KHOMEINE AND MARKAZE TEBI-KODAKAN HOSPITALS IN 1384. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 12(36), 19-22. SID. https://sid.ir/paper/52953/en

Vancouver: Copy

SHAH CHERAGHI F., NIKBIN V.A.S.. INVESTIGATION OF METALO -BETA- LACTAMASE AND DETERMINATION OF ANTIBIOTIC RESISTANCE TO CEFTAZIDIME AND IMIPENEM TO P.AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS IN EMAM KHOMEINE AND MARKAZE TEBI-KODAKAN HOSPITALS IN 1384. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2007;12(36):19-22. Available from: https://sid.ir/paper/52953/en

IEEE: Copy

F. SHAH CHERAGHI, and V.A.S. NIKBIN, “INVESTIGATION OF METALO -BETA- LACTAMASE AND DETERMINATION OF ANTIBIOTIC RESISTANCE TO CEFTAZIDIME AND IMIPENEM TO P.AERUGINOSA ISOLATED FROM CLINICAL SPECIMENS IN EMAM KHOMEINE AND MARKAZE TEBI-KODAKAN HOSPITALS IN 1384,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 12, no. 36, pp. 19–22, 2007, [Online]. Available: https://sid.ir/paper/52953/en

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