THREE LEISHMANIA INFECTIONS OF GERBILIDAE GROUP IN SANDFLIES FROM TWO KNOWN ZCL FOCI OF IRAN BY USING MOLECULAR TECHNIQUES

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PARVIZI P.; READY P.D.

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Journal Paper

Paper Information

Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2007 | Volume:12 | Issue:37 Page(s): 7-18

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Title

THREE LEISHMANIA INFECTIONS OF GERBILIDAE GROUP IN SANDFLIES FROM TWO KNOWN ZCL FOCI OF IRAN BY USING MOLECULAR TECHNIQUES

Author(s)

PARVIZI P. | READY P.D. | Issue Writer Certificate

Keywords

LEISHMANIA MAJORQ2

LEISHMANIA TURANICAQ3

LEISHMANIA GERBILLIQ3

ITS-RIBOSOMAL DNAQ3

DIAGNOSTIC NESTED PCRSQ3

Abstract

Background and Objective: Cutaneous leismaniasis is one of the sisx important tropical diseases. In Iran, three species of Leishmaniahave been incriminated as the causative agents of human leishmaniasis - in order of epidemiological importance, LEISHMANIA MAJOR, Leishmania tropica and Leishmania infantum. The objective of this research was to detect Leishmania species of mammals rather than previous reported from Iranian sandflies by using molecular tools.Material and methods: Using Nested PCR methods amplified two regions of the ribosomal RNA amplicon of Leishmania (ITS1-5.8S rRNA gene, and a micro satellite DNA region of ITS2), which were shown to be species-specific by DNA sequence or fragment size.Results: The PCR assays detected in Iranian sand flies not only LEISHMANIA MAJOR but also for the first time L turanica and L. gerbilli sensu lato, two other parasites of the great gerbil. All three parasites were found in the northeast and centre of Iran, in two foci of rural Zoonotic Cutaneous Leishmaniasis (ZCL) caused by L. major. Fifty infections were detected in common sandfly species: at least seven geographically differentiated haplotypes of L. major in four-five species (Phlebotomus papatasi, P. caucasicus or the isomorphic P. mongolensis, P. sergenti and Sergentomyia sintoni); one strain of L. gerbilli s.l. in five-six species (the above plus P. ansarii); and one strain of L. turanica in one species (P.papatasi).Conclusion: Relative infection rates suggest that more than one of these sandflies might be the vectors of L. major (including P. papatasi, P. caucasicus and P. mongolensis) and L. gerbilli s.l. (including S. sintoni but excluding P. papatasi), but that only P. papatasi is likely to be the vector of L. turanica. This is further evidence for considering P. papatasi to play the key vectorial role in ZCL foci, given the importance of L. turanica for maintaining Leishmania infections in gerbils.

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APA: Copy

PARVIZI, P., & READY, P.D.. (2007). THREE LEISHMANIA INFECTIONS OF GERBILIDAE GROUP IN SANDFLIES FROM TWO KNOWN ZCL FOCI OF IRAN BY USING MOLECULAR TECHNIQUES. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 12(37), 7-18. SID. https://sid.ir/paper/52960/en

Vancouver: Copy

PARVIZI P., READY P.D.. THREE LEISHMANIA INFECTIONS OF GERBILIDAE GROUP IN SANDFLIES FROM TWO KNOWN ZCL FOCI OF IRAN BY USING MOLECULAR TECHNIQUES. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2007;12(37):7-18. Available from: https://sid.ir/paper/52960/en

IEEE: Copy

P. PARVIZI, and P.D. READY, “THREE LEISHMANIA INFECTIONS OF GERBILIDAE GROUP IN SANDFLIES FROM TWO KNOWN ZCL FOCI OF IRAN BY USING MOLECULAR TECHNIQUES,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 12, no. 37, pp. 7–18, 2007, [Online]. Available: https://sid.ir/paper/52960/en

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