THE ROLE OF CHROMOSOMAL ABERRATION IN CHILDHOOD LEUKEMIA

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HASANZADEH NAZARABADI M.; MODARESI A.; MIRANPOUR H.

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Journal Paper

Paper Information

Journal: Journal of Sciences, Islamic Republic of Iran Year:2004 | Volume:15 | Issue:3 Page(s): 219-225

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Information Journal Paper

Title

THE ROLE OF CHROMOSOMAL ABERRATION IN CHILDHOOD LEUKEMIA

Author(s)

HASANZADEH NAZARABADI M. | MODARESI A. | MIRANPOUR H. | Issue Writer Certificate

Keywords

CHROMOSOMAL ABNORMALITIES; CHILDHOOD ACUTE LEUKEMIA; ALL; AML

Abstract

Leukemia is referred to a group of hetrogenous neoplasia, which results from the hematopoietic cells transformation. Various chromosomal abnormalities have been recognized as primary patogenetic changes. Clonal chromosomal aberration is found in approximately 80% of childhood acute leukemia. Favourable and poor prognosis karyotypes are evident in such patients. Since cytogenetic play a dominant role in outcome of patients with childhood acute leukemia it is important to associate characteristic cytogenetic with prognostic value in relation to chromosomal abnormalities. Cytogenetic analysis from 51 childhood diagnosed patients under the age of 14 has been performed on the basis of G-banding technique. Each pair of chromosome show unique banding pattern. Various chromosomal abnormalities were evident in this study, these include; numerical disorders such as: monosomy, trisomy, tetrasomy, pentasomy and pseudodiploidy. Among them monosomies were more prominent than the other aneuploidy. Structural aberrations such as philadelphia chromosome, gain and loss, inversion and breakage were seen. Each kind of childhood acute leukemia shows different responses to chemotherapy following cytogenetic studies. This finding strongly suggests that, a close association exists between chromosomal abnormalities and the prognostic value and prediction of outcome.

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APA: Copy

HASANZADEH NAZARABADI, M., MODARESI, A., & MIRANPOUR, H.. (2004). THE ROLE OF CHROMOSOMAL ABERRATION IN CHILDHOOD LEUKEMIA. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, 15(3), 219-225. SID. https://sid.ir/paper/529620/en

Vancouver: Copy

HASANZADEH NAZARABADI M., MODARESI A., MIRANPOUR H.. THE ROLE OF CHROMOSOMAL ABERRATION IN CHILDHOOD LEUKEMIA. JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN[Internet]. 2004;15(3):219-225. Available from: https://sid.ir/paper/529620/en

IEEE: Copy

M. HASANZADEH NAZARABADI, A. MODARESI, and H. MIRANPOUR, “THE ROLE OF CHROMOSOMAL ABERRATION IN CHILDHOOD LEUKEMIA,” JOURNAL OF SCIENCES ISLAMIC REPUBLIC OF IRAN, vol. 15, no. 3, pp. 219–225, 2004, [Online]. Available: https://sid.ir/paper/529620/en

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