THE PREVALENCE OF ISONIAZID-INDUCED PERIPHERAL NEUROPATHY

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EMAD M.R.; ALAVIAN GHAVANINI M.R.; SEDAGHAT P.; HAGHPANAH SEZANEH

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Journal: Iranian Journal of Infectious Diseases and Tropical Medicine Year:2002 | Volume:7 | Issue:19 Page(s): 54-60

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Title

THE PREVALENCE OF ISONIAZID-INDUCED PERIPHERAL NEUROPATHY

Author(s)

EMAD M.R. | ALAVIAN GHAVANINI M.R. | SEDAGHAT P. | HAGHPANAH SEZANEH | Issue Writer Certificate

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Abstract

Isoniazid (INH) as the most important first order antituberculosis medication, should be present in all treatment regimens. Peripheral neuropathy (PNP) due to disturbance of pyridoxine metabolism is one of the most common side effects of this drug. In our study, 70 cases with active tuberculosis (Pulmonary & extrapulmonary ) at least for 2 months on isoniazid without other risk factors for PNP were selected. Non of them were receiving pyridoxine supplement. They were 32 women and 38 men between 12- 67 years old. Nerve conduction velocity (NCV) and amplitude were measured in median and tibial motor nerves, also in ulnar and sural sensory nerves.Total incidence of PNP was 27 % and the most commonly involved nerves (in decreasing order) were sural 22. 8 % , ulnar 20% , tibial 17. 1% and median 5.7%. Therefore INH- Induced PNP is predominantly sensory and involves lower extremities more than upper ones. Axonal damage was the most common cause of PNP. 73. 6% of patients had involvement of more than one nerve. Only 15% of patients were symptomatic that indicates delayed appearance of clinical, compared to electrophysiological findings.

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APA: Copy

EMAD, M.R., ALAVIAN GHAVANINI, M.R., SEDAGHAT, P., & HAGHPANAH, SEZANEH. (2002). THE PREVALENCE OF ISONIAZID-INDUCED PERIPHERAL NEUROPATHY. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 7(19), 54-60. SID. https://sid.ir/paper/53020/en

Vancouver: Copy

EMAD M.R., ALAVIAN GHAVANINI M.R., SEDAGHAT P., HAGHPANAH SEZANEH. THE PREVALENCE OF ISONIAZID-INDUCED PERIPHERAL NEUROPATHY. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE[Internet]. 2002;7(19):54-60. Available from: https://sid.ir/paper/53020/en

IEEE: Copy

M.R. EMAD, M.R. ALAVIAN GHAVANINI, P. SEDAGHAT, and SEZANEH HAGHPANAH, “THE PREVALENCE OF ISONIAZID-INDUCED PERIPHERAL NEUROPATHY,” IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, vol. 7, no. 19, pp. 54–60, 2002, [Online]. Available: https://sid.ir/paper/53020/en

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