DEGRADITION OF POLY (D,L-LACTIDE-CO-GLYCOLIDE) 50:50 IMPLANT IN AQUEOUS MEDIUM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DARESTANI FARAHANI T.; ABTAHI MOJTABA; ENTEZAMI A.A.; MOBEDI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2005 | Volume:14 | Issue:8 (62) Page(s): 753-763

Download Full-Text

View:

631

Download:

715

Cites:

Information Journal Paper

Title

DEGRADITION OF POLY (D,L-LACTIDE-CO-GLYCOLIDE) 50:50 IMPLANT IN AQUEOUS MEDIUM

Author(s)

DARESTANI FARAHANI T. | ABTAHI MOJTABA | ENTEZAMI A.A. | MOBEDI H. | Issue Writer Certificate

Keywords

DEGRADATION

POLY(D

L-LACTIDE-CO-GLYCOLIDE)

IMPLANT

IN VITRO

LACTIC ACID

Abstract

Aliphatic polyesters are the source of the attractive polymeric matrices that are currently investigated for making controlled drug delivery devices. In spite of the large number of investigations dealing with LA/GA polymers which have been reported in the literature, only little is known about the DEGRADATION mechanism of these polyesters in solid state. In this study poly (L,D-lactide-co-glycolide) 50:50 (PLGA) was hydrolyzed at 37oC for periods up to 56 days. PLGA discs were prepared in 60oC and the results of their in vitro bioDEGRADATION behaviour are reported. We observed that hydrolysis of PLGA proceeds in 7 stages: surface hydrolysis ,outer layers hydrolysis, outer layers water soluble oligomers formation, exiting water soluble oligomers, bulk hydrolysis and exiting DEGRADATION products, bulk catalyzed hydrolysis, and at the last step fragile porous structure formation. The remained porous structure is crystallized and shows more resistance to further DEGRADATION.

Cites

BIOCOMPATIBILITY AND BIODEGRADATION OF POLY (D,L-LACTIC-CO-GLYCOLIC ACID) 90/10: IN VITRO AND IN VIVO ASSAYS

References

No record.

Cite

APA: Copy

DARESTANI FARAHANI, T., ABTAHI, MOJTABA, ENTEZAMI, A.A., & MOBEDI, H.. (2005). DEGRADITION OF POLY (D,L-LACTIDE-CO-GLYCOLIDE) 50:50 IMPLANT IN AQUEOUS MEDIUM . IRANIAN POLYMER JOURNAL (ENGLISH), 14(8 (62)), 753-763. SID. https://sid.ir/paper/533362/en

Vancouver: Copy

DARESTANI FARAHANI T., ABTAHI MOJTABA, ENTEZAMI A.A., MOBEDI H.. DEGRADITION OF POLY (D,L-LACTIDE-CO-GLYCOLIDE) 50:50 IMPLANT IN AQUEOUS MEDIUM . IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2005;14(8 (62)):753-763. Available from: https://sid.ir/paper/533362/en

IEEE: Copy

T. DARESTANI FARAHANI, MOJTABA ABTAHI, A.A. ENTEZAMI, and H. MOBEDI, “DEGRADITION OF POLY (D,L-LACTIDE-CO-GLYCOLIDE) 50:50 IMPLANT IN AQUEOUS MEDIUM ,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 14, no. 8 (62), pp. 753–763, 2005, [Online]. Available: https://sid.ir/paper/533362/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops