A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEYDARI JAVAD; HESHMAT RAMIN; AMIRI P.; FAKHRZADEH H.; PAZHOUHI M.; AKRAMI S.M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2006 | Volume:5 | Issue:3 Page(s): 209-215

Download Full-Text

Persian Verion

View:

946

Download:

Cites:

Information Journal Paper

Title

A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION

Author(s)

Keywords

UCP2Q3

POLYMORPHISMQ2

PCR/RFLPQ3

Abstract

Background: Uncoupling protein-2 (UCP2), one of the mitochondrial transporter memborane protiens, is suggested as a contributor gene for obesity. A common G/A POLYMORPHISM in the UCP2 promoter region is associated with obesity and diabetes. Methods: As a cross-sectional study, 75 healthy 25-64 years volunteers were randomly selected from Tehran University of Medical Sciences population Lab. DNA was exracted from blood samples then POLYMORPHISM and A & G Allel frequencies were determined via PCR and RFLP. The correlation between genotype and such clinical and biochemical parameters as BMI, serum cholesterol and TG was investigated. Results were compared with other similar surveys.Results: The frequencies of the UCP2 -866G/A genotypes in 75 Iranian normal population were AA: 7 (9.4%), GA: 41 (54.6%), and GG: 27 (36%).Conclusion: Significantly higher HDL cholesterol was detected in people with GG allele (P=0.02) as compared with GA and AA alleles. 866 UCP2 G/A genotype frequencies in our study were significantly different as compared with Japanese population but no with European studies that may emphasize on genetical similarity between Iranian and European Caucasians populations.

Cites

References

CARDIOVASCULAR RISK FACTORS STUDY IN THE INHABITANTS OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES POPULATION LAB: STATISTICAL DESIGN AND SAMPLING

Cite

APA: Copy

HEYDARI, JAVAD, HESHMAT, RAMIN, AMIRI, P., FAKHRZADEH, H., PAZHOUHI, M., & AKRAMI, S.M.. (2006). A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 5(3), 209-215. SID. https://sid.ir/paper/53915/en

Vancouver: Copy

HEYDARI JAVAD, HESHMAT RAMIN, AMIRI P., FAKHRZADEH H., PAZHOUHI M., AKRAMI S.M.. A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2006;5(3):209-215. Available from: https://sid.ir/paper/53915/en

IEEE: Copy

JAVAD HEYDARI, RAMIN HESHMAT, P. AMIRI, H. FAKHRZADEH, M. PAZHOUHI, and S.M. AKRAMI, “A COMMON POLYMORPHISM IN THE PROMOTER OF UCP2 GENE IN AN IRANIAN NORMAL POPULATION,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 5, no. 3, pp. 209–215, 2006, [Online]. Available: https://sid.ir/paper/53915/en

Related Journal Papers