THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT

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SAYYAD ZOMORRODI MARIA; SHIRAVI ABDOLHOSSEIN

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Journal: Iranian Journal of Diabetes and Metabolism Year:2015 | Volume:15 | Issue:1 Page(s): 1-8

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Title

THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT

Author(s)

SAYYAD ZOMORRODI MARIA | SHIRAVI ABDOLHOSSEIN | Issue Writer Certificate

Keywords

DIABETES

RASPBERRY

WOUND HEALING

RAT

Abstract

Background: Diabetic foot ulcers are important topic in DIABETES care. DIABETES is one of the most common metabolic diseases of endocrinology. RASPBERRY (Rubus fruticosus) has anti-inflammatory, anti-septic and anti-oxidant effects. The aim of present study is healing effects of RASPBERRY extract on the regeneration process of skin wounds in control and diabetic RATs.Methods: In this study, 48 adult male RATs were divided into four groups (n=12 each) including: control group (non-treated and non-diabetic RATs), sham (eucerin-treated diabetic RATs), experimental1 (non-treated diabetic RATs) and experimental 2 (raspberry-treated diabetic RATs). DIABETES was induced by 55 mg/kg Streptozotocin (STZ) in three groups of RATs. A wound with 3 cm length was created on the skin of back side of animals in all groups. The experimental 1 group was treated by eucerin and experimental 2 groups were treated by RASPBERRY extract two times in a day. Microscopic and macroscopic studies were performed on WOUND HEALING process on days of 3, 5, 7, 14 and 21.Results: The findings showed that sham and experimental 1 group had later healing effect comparing with control group. The speed of WOUND HEALING in RASPBERRY extract-treated RATs (experimental 2 groups) had significantly increased in comparison with control group and the wound surface area has been significantly decreased in comparison with all other groups (P£0.05).Conclusion: It seems that topical application of RASPBERRY extract can accelerate the WOUND HEALING in diabetic RATs and materials in RASPBERRY extract stimulate the collagen synthesis, faster wound contraction and angiogenesis.

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APA: Copy

SAYYAD ZOMORRODI, MARIA, & SHIRAVI, ABDOLHOSSEIN. (2015). THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 15(1), 1-8. SID. https://sid.ir/paper/53918/en

Vancouver: Copy

SAYYAD ZOMORRODI MARIA, SHIRAVI ABDOLHOSSEIN. THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2015;15(1):1-8. Available from: https://sid.ir/paper/53918/en

IEEE: Copy

MARIA SAYYAD ZOMORRODI, and ABDOLHOSSEIN SHIRAVI, “THE STUDY EFFECT OF RUBUS FRUTICOSUS EXTRACT ON CUTANEOUS WOUND HEALING IN DIABETIC WISTAR RAT,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 15, no. 1, pp. 1–8, 2015, [Online]. Available: https://sid.ir/paper/53918/en

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