CANDIDATE GENE ANALYSIS IN DIABETIC RETINOPATHY: IGF-I GENE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAVAKOLI BAZAZ J.; PRAVICA V.; JM BOULTON A.; HUTCHINSON I.V.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2007 | Volume:7 | Issue:1 (22) Page(s): 35-42

Download Full-Text

Persian Verion

View:

825

Download:

Cites:

Information Journal Paper

Title

CANDIDATE GENE ANALYSIS IN DIABETIC RETINOPATHY: IGF-I GENE

Author(s)

TAVAKOLI BAZAZ J. | PRAVICA V. | JM BOULTON A. | HUTCHINSON I.V. | Issue Writer Certificate

Keywords

GENETICQ3

POLYMORPHISMQ2

DIABETIC RETINOPATHY‎Q3

IGF-1Q2

Abstract

Background: The alteration of IGF-I systemic level in diabetes is typically characterized by depletion of free IGF-I plasma level and its decreased bioavailability. With regard to protective and advantageous effects of IGF-I on tissue healing and cellular regeneration such depletion could facilitate or accelerate tissue damages and complications. By contrast, the local concentration of IGF-I is reportedly increased in particular tissues during some occasions, which has also clinical implications as IGF-I could function in an autocrine and paracrine manner.The present study was conducted to assess that whether the differential outcome of diabetic subjects relative to diabetic retinopathy (DR) is linked to some extent to the structural variations of IGF-I gene.Methods: Two POLYMORPHISMs of the IGF-I gene at positions –383*C/T and -1089*C/T were employed for genotyping analysis by ARMS-PCR assay and the data of genotype/allele distribution was compared between two subgroups of 248 British Caucasian type 1 diabetic subjects, 135 cases with DR and 113 controls (DR-).Results: The distribution of these POLYMORPHISMs did not associate significantly with presence or absence of DR (P≥ 0.05).Conclusion: Since the involvement of IGF-I in development of DR is fairly rational, our results firstly may reflect some reservations about the functionality of the employed polymorphic markers and secondly may indicate that all regulators of IGF-I functionality or its local concentration level including IGFBPs and IGFRs should be taken into account, so their genes could be the subject of new study to accomplish current investigation.

Cites

No record.

References

No record.

Cite

APA: Copy

TAVAKOLI BAZAZ, J., PRAVICA, V., JM BOULTON, A., & HUTCHINSON, I.V.. (2007). CANDIDATE GENE ANALYSIS IN DIABETIC RETINOPATHY: IGF-I GENE. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 7(1 (22)), 35-42. SID. https://sid.ir/paper/53935/en

Vancouver: Copy

TAVAKOLI BAZAZ J., PRAVICA V., JM BOULTON A., HUTCHINSON I.V.. CANDIDATE GENE ANALYSIS IN DIABETIC RETINOPATHY: IGF-I GENE. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2007;7(1 (22)):35-42. Available from: https://sid.ir/paper/53935/en

IEEE: Copy

J. TAVAKOLI BAZAZ, V. PRAVICA, A. JM BOULTON, and I.V. HUTCHINSON, “CANDIDATE GENE ANALYSIS IN DIABETIC RETINOPATHY: IGF-I GENE,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 7, no. 1 (22), pp. 35–42, 2007, [Online]. Available: https://sid.ir/paper/53935/en

Related Journal Papers