SERUM CYTOKERATIN-18 FRAGMENT LEVELS, PARAOXONASE ACTIVITY AND LIPID PROFILE OF NON-ALCOHOLIC FATTY LIVER IN IRAN

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TEIMOURI NAHID; NAYERI HASHEM

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Journal: Iranian Journal of Diabetes and Metabolism Year:2016 | Volume:15 | Issue:3 Page(s): 183-191

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Title

SERUM CYTOKERATIN-18 FRAGMENT LEVELS, PARAOXONASE ACTIVITY AND LIPID PROFILE OF NON-ALCOHOLIC FATTY LIVER IN IRAN

Author(s)

TEIMOURI NAHID | NAYERI HASHEM | Issue Writer Certificate

Keywords

NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)Q2

NON-ALCOHOLIC STEATOHEPATITIS (NASH)Q2

CYTOKERATIN 18 (CK-18)Q2

PARAOXONASESQ2

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease is increasing in adults and children worldwide. Obesity, insulin resistance or diabetes type II, hyperlipidemia and hypertriglyceridemia plays a major role in the epidemiology of this disease. Cytokeratin 18 (CK-18) the major intermediate filament protein in the liver is a marker of increased hepatocyte apoptosis.The aim of this study was todeterminate CK-18 level as a marker of hepatocyte apoptosis and paraoxonase as a biochemical marker for lipid peroxidation.Methods: This case–control study was done on 51 subjects with confirmed NAFLD by ultrasound and 30 healthy individuals. CK-18 is proposed as a biomarker alternative cell death. The serum was used for measurement of the apoptosis-associated neo-epitope in the C-terminal domain of CK-18 by the M30-Apoptosense ELISA kit. The M30 detection antibody recognizes a neo-epitope mapped to positions 387 to 396 of CK18, so called CK18-Asp396 that is only revealed after caspase cleavage of the protein and is postulated as a selective biomarker of apoptosis. Serum PON1 activity was assayed using a synthetic substrate. Paraoxon substrate (diethyl-p nitrophenylphosphate), was deliberated using the increase of absorbance at 412 nm at 37◦C.Results: There were significant differences regarding serum cytokeratin 18 (p=0.005), paraoxonase activity (p=0.03), triglycerides (p=0.04) and low-density lipoprotein (p=0.04) between NAFLD and healthy subjects.Between CK-18 and paraoxonase with the early stages of fatty liver disease are associated.Conclusion: This study suggests that serum levels of cytokeratin 18 can be useful in predicting nonalcoholic fatty liver disease. Paraoxonase activity (PON1) should be considered a biochemical marker of lipid peroxidation and the need for follow-up in patients with NAFLD.

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APA: Copy

TEIMOURI, NAHID, & NAYERI, HASHEM. (2016). SERUM CYTOKERATIN-18 FRAGMENT LEVELS, PARAOXONASE ACTIVITY AND LIPID PROFILE OF NON-ALCOHOLIC FATTY LIVER IN IRAN. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 15(3), 183-191. SID. https://sid.ir/paper/53992/en

Vancouver: Copy

TEIMOURI NAHID, NAYERI HASHEM. SERUM CYTOKERATIN-18 FRAGMENT LEVELS, PARAOXONASE ACTIVITY AND LIPID PROFILE OF NON-ALCOHOLIC FATTY LIVER IN IRAN. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2016;15(3):183-191. Available from: https://sid.ir/paper/53992/en

IEEE: Copy

NAHID TEIMOURI, and HASHEM NAYERI, “SERUM CYTOKERATIN-18 FRAGMENT LEVELS, PARAOXONASE ACTIVITY AND LIPID PROFILE OF NON-ALCOHOLIC FATTY LIVER IN IRAN,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 15, no. 3, pp. 183–191, 2016, [Online]. Available: https://sid.ir/paper/53992/en

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