FULL NATURAL HYDROGEL BEADS FOR CONTROLLED RELEASE OF ACETATE AND DISODIUM PHOSPHATE DERIVATIVES OF BETAMETHASONE

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MOHAMADNIA Z.; JAMSHIDI AHMAD; MOBEDI H.; ZOHOURIAN MEHR M.J.A.D.; AHMADI EBRAHIM

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Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2007 | Volume:16 | Issue:10 Page(s): 711-718

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Title

FULL NATURAL HYDROGEL BEADS FOR CONTROLLED RELEASE OF ACETATE AND DISODIUM PHOSPHATE DERIVATIVES OF BETAMETHASONE

Author(s)

Keywords

HYDROGEL

CARRAGEENAN

ALGINATE

DRUG DELIVERY

RELEASE

Abstract

Highly practical conditions were accomplished to prepare new ionically cross linked polymer network HYDROGEL beads (Caralgi) composed of polysaccharides carrageen an and sodium ALGINATE. Disodium phosphate and the acetate derivatives of betamethasone were simultaneously loaded while the HYDROGEL network was being formed. A maximum loading efficiency of 91% was achieved at pH 4.8 and temperature 75 ؛C. The morphology of the Caralgi HYDROGELs with and without drug was investigated using SEM analysis. A more regulated morphology was observed when the drug was incorporated into the HYDROGEL. The in vitro RELEASE behaviour of the drug loaded Caralgi samples prepared under various conditions was also studied. The full natural system has exhibited RELEASE behaviour with no burst effect. No major difference was found in the loading and RELEASE when a highly water-soluble derivative of the drug, i.e., betamethasone disodium phosphate was used.

Cites

HYDROGELS IN CONTROLLED DRUG DELIVERY SYSTEMS

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APA: Copy

MOHAMADNIA, Z., JAMSHIDI, AHMAD, MOBEDI, H., ZOHOURIAN MEHR, M.J.A.D., & AHMADI, EBRAHIM. (2007). FULL NATURAL HYDROGEL BEADS FOR CONTROLLED RELEASE OF ACETATE AND DISODIUM PHOSPHATE DERIVATIVES OF BETAMETHASONE. IRANIAN POLYMER JOURNAL (ENGLISH), 16(10), 711-718. SID. https://sid.ir/paper/540307/en

Vancouver: Copy

MOHAMADNIA Z., JAMSHIDI AHMAD, MOBEDI H., ZOHOURIAN MEHR M.J.A.D., AHMADI EBRAHIM. FULL NATURAL HYDROGEL BEADS FOR CONTROLLED RELEASE OF ACETATE AND DISODIUM PHOSPHATE DERIVATIVES OF BETAMETHASONE. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2007;16(10):711-718. Available from: https://sid.ir/paper/540307/en

IEEE: Copy

Z. MOHAMADNIA, AHMAD JAMSHIDI, H. MOBEDI, M.J.A.D. ZOHOURIAN MEHR, and EBRAHIM AHMADI, “FULL NATURAL HYDROGEL BEADS FOR CONTROLLED RELEASE OF ACETATE AND DISODIUM PHOSPHATE DERIVATIVES OF BETAMETHASONE,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 16, no. 10, pp. 711–718, 2007, [Online]. Available: https://sid.ir/paper/540307/en

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