THE ROLE OF HOMOCYSTEINE IN HEALTH AND DISEASE

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FAKHRZADEH H.; GHOTBI SARA; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Iranian Journal of Diabetes and Metabolism Year:2008 | Volume:7 | Issue:2 (23) Page(s): 135-149

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Title

THE ROLE OF HOMOCYSTEINE IN HEALTH AND DISEASE

Author(s)

FAKHRZADEH H. | GHOTBI SARA | ARDESHIR LARIJANI MOHAMMAD BAGHER | Issue Writer Certificate

Keywords

HOMOCYSTEINEQ3

FOLIC ACIDQ2

VITAMIN BQ3

CARDIOVASCULAR DISEASEQ3

Abstract

High plasma HOMOCYSTEINE is identified as an important risk factor for CARDIOVASCULAR DISEASE. Epidemiological studies have shown that increased plasma HOMOCYSTEINE is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease. HOMOCYSTEINE may have an effect on atherosclerosis by damaging the inner lining of arteries and promoting blood clots .Folic acid and other B group vitamins help break down HOMOCYSTEINE in the body and folate fortification of foods reduces the average HOMOCYSTEINE level in the population. Low blood levels of folate are also linked with a higher risk of fatal coronary heart disease and stroke. HOMOCYSTEINE levels are strongly influenced via diet, as well as via genetic factors. Many common genetic disorders and problems (such as vitamin deficiency) adversely affect the metabolism of HOMOCYSTEINE. Common causes of a high HOMOCYSTEINE level include dietary deficiency of folate and B group vitamins, hypothyroidism, kidney disease, psoriasis, and some medicines. Clinical trials to date have not provided consistent evidence that lowering HOMOCYSTEINE levels reduce strokes, heart attacks and other cardiovascular events; notwithstanding it is recommended to lower a high HOMOCYSTEINE level because it is a risk factor for heart disease. HOMOCYSTEINE abnormalities also contribute to birth defects and dementia and FOLIC ACID supplementation in the pre-conceptual period is effective in preventing recurrent and primary neural tube defects.

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APA: Copy

FAKHRZADEH, H., GHOTBI, SARA, & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2008). THE ROLE OF HOMOCYSTEINE IN HEALTH AND DISEASE. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 7(2 (23)), 135-149. SID. https://sid.ir/paper/54094/en

Vancouver: Copy

FAKHRZADEH H., GHOTBI SARA, ARDESHIR LARIJANI MOHAMMAD BAGHER. THE ROLE OF HOMOCYSTEINE IN HEALTH AND DISEASE. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2008;7(2 (23)):135-149. Available from: https://sid.ir/paper/54094/en

IEEE: Copy

H. FAKHRZADEH, SARA GHOTBI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “THE ROLE OF HOMOCYSTEINE IN HEALTH AND DISEASE,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 7, no. 2 (23), pp. 135–149, 2008, [Online]. Available: https://sid.ir/paper/54094/en

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