THE COMPARISON STUDY TO CONSIDER THE EFFICACY OF ROFECOXIB (COX II INHIBITOR) WITH IBUPROFEN IN DENTAL PAIN AFTER ONE VISIT ROOT CANAL THERAPY (RESEARCH)

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ESHRAF H.; REZAEI F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: JOURNAL OF ISLAMIC DENTAL ASSOCIATION OF IRAN (MAJALLAH-I-DANDANPIZISHKI) Year:2002 | Volume:14 | Issue:3 (42) Page(s): 47-59

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Title

THE COMPARISON STUDY TO CONSIDER THE EFFICACY OF ROFECOXIB (COX II INHIBITOR) WITH IBUPROFEN IN DENTAL PAIN AFTER ONE VISIT ROOT CANAL THERAPY (RESEARCH)

Author(s)

ESHRAF H. | REZAEI F. | Issue Writer Certificate

Keywords

ROFECOXIBQ4

IBUPROFENQ4

POST OPERATIVE ENDODONTIC PAINQ4

CYCLOXYGENASEQ4

SPECIFIC INHIBITORQ4

ANALGESICQ4

Abstract

Previous data have suggested that ROFECOXIB A Cox-2-specific inhibitor has ANALGESIC effect similar to those of the nonstroidal anti inflammatory drugs when tested in post dental surgery. The purpose of this study was to determine the ANALGESIC efficacy of a single dose of ROFECOXIB 50 mg once daily compared with the four doses of IBUPROFEN and placebo after one visit root canal therapy in endonontic emergency patient. In this randomized double blind, placebo --controlled, parallel group study,60 patients (57% men, Mean age; 28.4) with sever pain in the study defined as 7 and more using a visual analog scale in molar teeth invited to participate. Which was after one visit of the root canal therapy randomly receive a single dose of ROFECOXIB or four doses of IBUPROFEN or placebo.Analgesic efficacy was assessed for up to 24 hrs (6h, 12h, 24h) post dose using self administration questionnaire. A total of 60 patient were enrolled. 20 receive ROFECOXIB50 mg. 20 receive IBUPROFEN 400mg every 6 h. 20 receive placebo. The ANALGESIC efficacy of ROFECOXIB and IBUPROFEN was higher than placebo and this difference was significant. Comparing ROFECOXIB and IBUPROFEN there was not significant differences but ROFECOXIB had longer duration of action. We concluded that ROFECOXIB was efficatious in control of post operative dental pain and that Cox-2 derived prostanoid play a role in treatment of pain associated with root canal therapy. On the base of our study we do recomment to prescribe single dose ROFECOXIB per day after Irreversible pulpitis treatment rather than 4 dose of IBUPROFEN.

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APA: Copy

ESHRAF, H., & REZAEI, F.. (2002). THE COMPARISON STUDY TO CONSIDER THE EFFICACY OF ROFECOXIB (COX II INHIBITOR) WITH IBUPROFEN IN DENTAL PAIN AFTER ONE VISIT ROOT CANAL THERAPY (RESEARCH). JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), 14(3 (42)), 47-59. SID. https://sid.ir/paper/54690/en

Vancouver: Copy

ESHRAF H., REZAEI F.. THE COMPARISON STUDY TO CONSIDER THE EFFICACY OF ROFECOXIB (COX II INHIBITOR) WITH IBUPROFEN IN DENTAL PAIN AFTER ONE VISIT ROOT CANAL THERAPY (RESEARCH). JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI)[Internet]. 2002;14(3 (42)):47-59. Available from: https://sid.ir/paper/54690/en

IEEE: Copy

H. ESHRAF, and F. REZAEI, “THE COMPARISON STUDY TO CONSIDER THE EFFICACY OF ROFECOXIB (COX II INHIBITOR) WITH IBUPROFEN IN DENTAL PAIN AFTER ONE VISIT ROOT CANAL THERAPY (RESEARCH),” JOURNAL OF IRANIAN DENTAL ASSOCIATION (JIDA) (MAJALLAH-I-DANDANPIZISHKI), vol. 14, no. 3 (42), pp. 47–59, 2002, [Online]. Available: https://sid.ir/paper/54690/en

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