INHERITED TROMBOPHILIC STATES AND PULMONARY EMBOLISM

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KONECNY F.

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Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2009 | Volume:14 | Issue:1 Page(s): 43-56

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Information Journal Paper

Title

INHERITED TROMBOPHILIC STATES AND PULMONARY EMBOLISM

Author(s)

KONECNY F. | Issue Writer Certificate

Keywords

INHERITED THROMBOPHILIC STATES

VENOUS THROMBOEMBOLISM

PULMONARY EMBOLISM

Abstract

Pulmonary embolism (PE) and deep vein thrombosis (DVT) are associated with considerable morbidity and mortality, mostly, in case of PE for its lack of sensitivity of its early detection. For as much as twenty-five percent of PE patients the primary clinical appearance is unexpected death. While PE is one of the most avertable causes of hospital-associated deaths, its diagnostics can be extremely difficult. Newly increased interest in an INHERITED THROMBOPHILIC STATES has been provoked by the discovery of several common inherited abnormalities, i.e. the prothrombin (PT) gene G20210A, Factor V Leiden (FVL) mutation (Arg506Gln), hyperhomocystenemia and homocysteiuria, Wein-Penzing defect, Sticky Platelet Syndrome (SPS), Quebec platelet disorder (QPD) and Sickle Cell Disease (SCD). PE incidence rates increase exponentially with age for both men and women, as they might harbor more than one thrombophilic state. Although the impact of genetic factors on PE is to some extent documented with lacking taxonomy, its genetic testing as its prevention strategy fall short.In this review thrombophilic states are divided into inherited or acquired, and only the inherited and newly documented are more closely followed. Factors are further grouped based on its thrombophilic taxonomy into; inherited defects of coagulation, inherited defects of fibrinolysis, inherited defects of enzymatic pathway in relation to development of VTE and PE and inherited defects of platelets in relation to PE. It was beyond the scope of this review to follow all inherited and newly recognized factors and its association to VTE and PE; however the overall taxonomy makes this review clinically valuable i.e. in relation to genetic testing as PE prevention.

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APA: Copy

KONECNY, F.. (2009). INHERITED TROMBOPHILIC STATES AND PULMONARY EMBOLISM. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 14(1), 43-56. SID. https://sid.ir/paper/548617/en

Vancouver: Copy

KONECNY F.. INHERITED TROMBOPHILIC STATES AND PULMONARY EMBOLISM. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2009;14(1):43-56. Available from: https://sid.ir/paper/548617/en

IEEE: Copy

F. KONECNY, “INHERITED TROMBOPHILIC STATES AND PULMONARY EMBOLISM,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 14, no. 1, pp. 43–56, 2009, [Online]. Available: https://sid.ir/paper/548617/en

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