RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SOBHANI MARYAM; IZADI P.; GHAVAMZADEH ARDESHIR; ALI MOGHADAM K.; IRAVANI M.; JAHANI M.; MOUSAVI ASAD ELAH; HADI ASHAR N.; NOURI DALOUEI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: The Scientific Journal of Iranian Blood Transfusion Year:2007 | Volume:4 | Issue:3 (15) Page(s): 175-180

Download Full-Text

View:

234

Download:

Cites:

Information Journal Paper

Title

RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR

Author(s)

Keywords

BONE MARROW TRANSPLANTATION

GENOTYPE

GRAFT VERSUS HOST DISEASE

Abstract

Background and Objectives: GVHD occurs in 20--40% of recipients of HLA-matched sibling donor grafts. A number of studies suggest that polymorphism in cytokine genes influence susceptibility to post-BMT complications. One of the cytokine gene family (IL-IRN) encodes IL-l receptor antagonist (IL-IRa), an anti-inflammatory molecule that competes for receptor binding with IL-la and IL-I~. The overall contribution of IL-1 to the proinflammatory response depends on the balance between these three molecules. In this study, we decided to evaluate the polymorphisms of IL-1Ra gene that might influence the outcome of BMT. Materials and Methods: In this cohort study, patients' (n = 175) and donors' (n = 175) DNA from a total of 350 human leucocyte antigen (HLA)-identical sibling allogeneic BMTs were analysed. IL-1Ra gene polymorphism was studied by PCR-VNTR method. PCR products were then visualized by electrophoresis in 2% agarose gel. Then, the correlation between donor and recipient GENOTYPE and GVHD grade for their respective transplant was assessed. Results: The frequency of the aGVHD grades was divided to grade 0 (38.3%), grade I (17.7%), grade II (27.4%), grade III (13.7%), grade IV (2.9%). Correlation between donor and recipient GENOTYPE and GVHD grade for their respective transplant was assessed. We observed no significant correlation between the IL-1Ra polymorphism and incidence of aGVHD, although possession of the allele 2 in the individual GENOTYPE was associated with less severe acute GVHD. Conclusions: The observed allele frequencies were different from those previously reported. None of the polymorphisms showed association with the presence of acute GVHD. However, presence of allele 2 showed association with aGVHD. If the recipient possesed allele 2, the probability of aGVHD was 46% and in the absence of allele 2, it was 62%. Recipient age, donor age, recipient disease particularly thalassemia were the most remarkable risk factors for acute GVHD.

Cites

No record.

References

No record.

Cite

APA: Copy

SOBHANI, MARYAM, IZADI, P., GHAVAMZADEH, ARDESHIR, ALI MOGHADAM, K., IRAVANI, M., JAHANI, M., MOUSAVI, ASAD ELAH, HADI ASHAR, N., & NOURI DALOUEI, M.R.. (2007). RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 4(3 (15)), 175-180. SID. https://sid.ir/paper/551682/en

Vancouver: Copy

SOBHANI MARYAM, IZADI P., GHAVAMZADEH ARDESHIR, ALI MOGHADAM K., IRAVANI M., JAHANI M., MOUSAVI ASAD ELAH, HADI ASHAR N., NOURI DALOUEI M.R.. RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2007;4(3 (15)):175-180. Available from: https://sid.ir/paper/551682/en

IEEE: Copy

MARYAM SOBHANI, P. IZADI, ARDESHIR GHAVAMZADEH, K. ALI MOGHADAM, M. IRAVANI, M. JAHANI, ASAD ELAH MOUSAVI, N. HADI ASHAR, and M.R. NOURI DALOUEI, “RELATIONSHIP BETWEEN IL-1RA GENE POLYMORPHISM AND GVHD AS A PROGNOSTIC FACTOR,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 4, no. 3 (15), pp. 175–180, 2007, [Online]. Available: https://sid.ir/paper/551682/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops