مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

EFFECT OF CELL WALL, CYTOPLASMIC FRACTION AND KILLED-CANDIDA ALBICANS ON NITRIC OXIDE PRODUCTION BY PERITONEAL MACROPHAGES FROM BALB/C MICE

Pages

  86-92

Abstract

 Objective(s): The fractions of CANDIDA ALBICANS have been used as an immunomodulator. The present work assessed the effect of different fractions of C. albicans on NITRIC OXIDE (NO) production by mice peritoneal MACROPHAGES.Materials and Methods: Cell wall and cytoplasmic fractions of C. albicans ATCC 10321 strain were extracted. Mice peritoneal MACROPHAGES were purified and cultured. Different concentrations of both fractions and also killed C. albicans cells were used for MACROPHAGES stimulation and evaluation of NO production. NO amount was detected in culture supernatants of MACROPHAGES by Griess reagent. Also, MTT assay was performed to assess the viability of MACROPHAGES.Results: The results elucidated that suppressive effect of cell wall proteins on NO release was significant at the dose of 100 mg/ml (P=0.01), while cytoplasmic fraction increased NO amount at the dose of 1 mg/ml compared to the control group (P=0.003). Augmentation of NO production was statistically significant at 200 killed C. albicans per well (P=0.006).Conclusion: According to our findings, cytoplasmic fractions and killed C. albicans have a positive effect on NO production by peritoneal MACROPHAGES, while cell wall fractions did not. Therefore, it is proposed that C. albicans fractions can be studied more as inflammation modulators.

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    APA: Copy

    HAJIMORADI, M., DANESHMANDI, S., ROUDBARI, MARYAM, ROUDBAR MOHAMMADI, SH., MOHAMMAD HASAN, ZOHEYR, HEYDARI, ROZITA, & NAMDAR AHMADABAD, H.. (2009). EFFECT OF CELL WALL, CYTOPLASMIC FRACTION AND KILLED-CANDIDA ALBICANS ON NITRIC OXIDE PRODUCTION BY PERITONEAL MACROPHAGES FROM BALB/C MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 12(2 (42)), 86-92. SID. https://sid.ir/paper/555106/en

    Vancouver: Copy

    HAJIMORADI M., DANESHMANDI S., ROUDBARI MARYAM, ROUDBAR MOHAMMADI SH., MOHAMMAD HASAN ZOHEYR, HEYDARI ROZITA, NAMDAR AHMADABAD H.. EFFECT OF CELL WALL, CYTOPLASMIC FRACTION AND KILLED-CANDIDA ALBICANS ON NITRIC OXIDE PRODUCTION BY PERITONEAL MACROPHAGES FROM BALB/C MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2009;12(2 (42)):86-92. Available from: https://sid.ir/paper/555106/en

    IEEE: Copy

    M. HAJIMORADI, S. DANESHMANDI, MARYAM ROUDBARI, SH. ROUDBAR MOHAMMADI, ZOHEYR MOHAMMAD HASAN, ROZITA HEYDARI, and H. NAMDAR AHMADABAD, “EFFECT OF CELL WALL, CYTOPLASMIC FRACTION AND KILLED-CANDIDA ALBICANS ON NITRIC OXIDE PRODUCTION BY PERITONEAL MACROPHAGES FROM BALB/C MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 12, no. 2 (42), pp. 86–92, 2009, [Online]. Available: https://sid.ir/paper/555106/en

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