PREPARATION AND CHARACTERIZATION OF AGKISTRODON HALYS VENOM ENTRAPPED CHITOSAN NANOPARTICLES: NOVEL AND ADVANCED ANTIGEN DELIVERY AND ADJUVANT SYSTEM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mohammadpour Dounighi Naser; JAVADI MAHSHID; ZOLFAGHARIAN HOSSEIN; AWADI MOHAMMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2016 | Volume:23 | Issue:5 Page(s): 618-630

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,503

Download:

Cites:

Information Journal Paper

Title

PREPARATION AND CHARACTERIZATION OF AGKISTRODON HALYS VENOM ENTRAPPED CHITOSAN NANOPARTICLES: NOVEL AND ADVANCED ANTIGEN DELIVERY AND ADJUVANT SYSTEM

Author(s)

Mohammadpour Dounighi Naser | JAVADI MAHSHID | ZOLFAGHARIAN HOSSEIN | AWADI MOHAMMAD REZA | Issue Writer Certificate

Keywords

CHITOSANQ1

NANOPARTICLESQ1

AGKISTRODON HALYSQ1

VENOMQ2

IONIC GELATIONQ2

Abstract

Background & Aims: In recent years, the feasibility of hydrophilic NANOPARTICLES has been broadly investigated for use in drug delivery and therapeutic systems. Due to the problems of traditional adjuvants, in this study AGKISTRODON HALYS (Ah) Snake VENOM was loaded in CHITOSAN NANOPARTICLES (CS NPs) in order to be used as an advanced adjuvant and antigen delivery system in antidote production industry.Methods: CS NPs containing Ah VENOM were prepared using IONIC GELATION and crosslinker method. In this study, polymer concentration, cross-linker concentration, particles size, particle size distribution, zeta potential, particles shape and surface characteristics, loading efficiency, loading capacity, and particles structure were optimized.Results: Optimum concentration achieved were CHITOSAN 2mg/ml and cross-linker 1mg/ml and AGKISTRODON HALYS snake venum 500 mg/ml. Mean particle size, polydispersity index (PDI), and zeta potential of VENOM-loaded CS NPs were respectively 129 nm, 0.418 and 41 mV. The loading capacity (LC) and loading efficiency (LE) were 82±1.9 and 88±2.1, respectively. Fourier transform infrared spectroscopy of NANOPARTICLES showed between CHITOSAN and cross linker. An initial burst release and second slow release up to 96 hours was observed.Conclusion: The obtained results suggested that VENOM-loaded CS NPs could be a suitable alternative to conventional adjuvant for manufacturing antivenom.

Cites

No record.

References

No record.

Cite

APA: Copy

Mohammadpour Dounighi, Naser, JAVADI, MAHSHID, ZOLFAGHARIAN, HOSSEIN, & AWADI, MOHAMMAD REZA. (2016). PREPARATION AND CHARACTERIZATION OF AGKISTRODON HALYS VENOM ENTRAPPED CHITOSAN NANOPARTICLES: NOVEL AND ADVANCED ANTIGEN DELIVERY AND ADJUVANT SYSTEM. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 23(5), 618-630. SID. https://sid.ir/paper/558/en

Vancouver: Copy

Mohammadpour Dounighi Naser, JAVADI MAHSHID, ZOLFAGHARIAN HOSSEIN, AWADI MOHAMMAD REZA. PREPARATION AND CHARACTERIZATION OF AGKISTRODON HALYS VENOM ENTRAPPED CHITOSAN NANOPARTICLES: NOVEL AND ADVANCED ANTIGEN DELIVERY AND ADJUVANT SYSTEM. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(5):618-630. Available from: https://sid.ir/paper/558/en

IEEE: Copy

Naser Mohammadpour Dounighi, MAHSHID JAVADI, HOSSEIN ZOLFAGHARIAN, and MOHAMMAD REZA AWADI, “PREPARATION AND CHARACTERIZATION OF AGKISTRODON HALYS VENOM ENTRAPPED CHITOSAN NANOPARTICLES: NOVEL AND ADVANCED ANTIGEN DELIVERY AND ADJUVANT SYSTEM,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 5, pp. 618–630, 2016, [Online]. Available: https://sid.ir/paper/558/en

Related Journal Papers