مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

357
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

114
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

DELAYED SYNAPTIC CHANGES IN AXOTOMIZED SPINAL MOTONEURONS OF NEWBORN RATS ASSOCIATED WITH PROGRESSIVE NEURONAL LOSS: IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL, AND QUANTITATIVE STUDY

Pages

  161-168

Abstract

 Background and Objective: SCIATIC NERVE transection is characterized by a rapid wave of MOTONEURON death associated with progressive synaptic lesions. The purpose of this study was to evaluate the long term synaptic changes. Materials and Methods: This basic study was carried out on paraffin- or resin-embedded tissue blocks for evaluation of synaptophysin and choline acetyl transaferase (CHAT) immunoreactivities and the ultrastructural changes in the synapses of spinal MOTONEURONs following SCIATIC NERVE AXOTOMY in the newborn rats. Results: The results showed that there was a progressive decrease in the percentage of survived MOTONEURONs and high percentage of chromatolytic MOTONEURONs. There was also a high percentage of degenerated MOTONEURONs with dotted pattern synaptophysin immunoreactivity, low percentage of intact MOTONEURONs with complete synaptophysin labeling, and high percentage of MOTONEURONs with low CHAT labeling. The ultrastructural study showed that there were many MOTONEURONs with synaptic pathological changes including irregularity of the synaptic membrane and displacement of synaptic vesicles. Conclusion: The findings of this study indicate that there is a delayed synaptic lesion in axotomized MOTONEURONs of newborn rats.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    HESHMATI, MARJAN, & TIRAIHI, T.. (2006). DELAYED SYNAPTIC CHANGES IN AXOTOMIZED SPINAL MOTONEURONS OF NEWBORN RATS ASSOCIATED WITH PROGRESSIVE NEURONAL LOSS: IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL, AND QUANTITATIVE STUDY. IRANIAN JOURNAL OF PATHOLOGY (IJP), 1(4), 161-168. SID. https://sid.ir/paper/558197/en

    Vancouver: Copy

    HESHMATI MARJAN, TIRAIHI T.. DELAYED SYNAPTIC CHANGES IN AXOTOMIZED SPINAL MOTONEURONS OF NEWBORN RATS ASSOCIATED WITH PROGRESSIVE NEURONAL LOSS: IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL, AND QUANTITATIVE STUDY. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2006;1(4):161-168. Available from: https://sid.ir/paper/558197/en

    IEEE: Copy

    MARJAN HESHMATI, and T. TIRAIHI, “DELAYED SYNAPTIC CHANGES IN AXOTOMIZED SPINAL MOTONEURONS OF NEWBORN RATS ASSOCIATED WITH PROGRESSIVE NEURONAL LOSS: IMMUNOHISTOCHEMICAL, ULTRASTRUCTURAL, AND QUANTITATIVE STUDY,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 1, no. 4, pp. 161–168, 2006, [Online]. Available: https://sid.ir/paper/558197/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button