HODGKIN LYMPHOMA AND ANAPLASTIC VARIANTS OF NON-HODGKIN LYMPHOMA

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TABRIZCHEE HAMID; ESMAILI ARMITA; COGLIATTI SERGIO

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2011 | Volume:6 | Issue:4 Page(s): 193-201

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Title

HODGKIN LYMPHOMA AND ANAPLASTIC VARIANTS OF NON-HODGKIN LYMPHOMA

Author(s)

TABRIZCHEE HAMID | ESMAILI ARMITA | COGLIATTI SERGIO | Issue Writer Certificate

Keywords

HODGKINS LYMPHOMA

NON HODGKIN LYMPHOMA

DIAGNOSIS

IMMUNOHISTOCHEMISTRY

IRAN

Abstract

Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them.Materials and Methods: We included 61 cases diagnosed as CHL, ALCL, and anaplastic variant of DLBCL. We reviewed morphologic microscopic findings by conventional staining and IMMUNOHISTOCHEMISTRY (IHC) with antibodies against PAX-5, CD30, CD15, CD45, EMA, ALK-1, and LMP-1.Results: Fifty cases corresponded to CHL (81.97%), 4 cases to ALCL (6.56%), and 4 cases to DLBCL (6.56%) excluding 3 cases, which remained unclassifiable (4.92%). PAX-5 was expressed in 94% of CHL and 100% of DLBCL cases. LMP-1 was expressed in 52% of CHL and 25% of DLBCL cases. EMA was invariably expressed in all 4 cases of ALK+ALCL. It was expressed in 4/50 cases (8%) of CHL and in 2/4 cases (50%) of DLBCL. CD45 was expressed in all cases of ALCL and DLBCL but also in 3/50 cases (6%) of CHL.Conclusion: The differentiation between ALCL and CHL based on EMA and CD45 is not reliable.Utilization of PAX-5 in combination with other markers such as CD15 and LMP-1 is recommended.CD20 and PAX-5 are not too helpful in the differentiation of CHL and DLBCL, while CD15 and CD79a were found to be quite useful discriminative markers for this purpose.

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APA: Copy

TABRIZCHEE, HAMID, ESMAILI, ARMITA, & COGLIATTI, SERGIO. (2011). HODGKIN LYMPHOMA AND ANAPLASTIC VARIANTS OF NON-HODGKIN LYMPHOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP), 6(4), 193-201. SID. https://sid.ir/paper/561677/en

Vancouver: Copy

TABRIZCHEE HAMID, ESMAILI ARMITA, COGLIATTI SERGIO. HODGKIN LYMPHOMA AND ANAPLASTIC VARIANTS OF NON-HODGKIN LYMPHOMA. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2011;6(4):193-201. Available from: https://sid.ir/paper/561677/en

IEEE: Copy

HAMID TABRIZCHEE, ARMITA ESMAILI, and SERGIO COGLIATTI, “HODGKIN LYMPHOMA AND ANAPLASTIC VARIANTS OF NON-HODGKIN LYMPHOMA,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 6, no. 4, pp. 193–201, 2011, [Online]. Available: https://sid.ir/paper/561677/en

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