مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

485
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

332
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

A SUSTAINED RELEASE OF MODEL DRUG FROM A NOVEL POLYACRYLIC ACID-POLYALUMINIUM CHLORIDE SUPERABSORBENT

Pages

  531-540

Abstract

 A new kind of drug loaded superabsorbent polymer was prepared and the properties of drug delivery performance are reported in the current study. The superabsorbent polymer was prepared via a process in which POLYACRYLIC ACID (PAA) was cross-linked via complex formation with POLYALUMINIUM CHLORIDE (PAC) through AlCl3 hydrolysis under alkaline conditions followed by freeze drying. The drugs were loaded into the network structure of the superabsorbent during the complex formation of CROSS-LINKING process. The new drug loaded superabsorbents were prepared aiming to overcome the drawbacks of those prepared via conventional method. The loading as well as the SUSTAINED RELEASE of the model drug acetaminophen (AMP) using the prepared superabsorbent has been studied by UV-absorption spectroscopy, and compared with superabsorbent prepared via conventional free radical polymeri-zation method. It was found that the AMP loaded before complex formation of CROSS-LINKING process and showed a much better loading performance and drugs SUSTAINED RELEASE properties compared to the product with which AMP was added during the process of complex formation of CROSS-LINKING process. The drug release mechanism has been analyzed for the polymers with different CROSS-LINKING densities via numerical simulation based on different kinetic models as well as the Ritger-Peppas equation. At the same time, it is found that the AMP release rate at pH 4 is initially greater than that at pH 10 and release rate increases as temperature is increased.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    CHEN, Y., LIANG, Y., CHEN, M.N., GUO, Y.W., YE, Y.CH., & TAN, H.M.. (2010). A SUSTAINED RELEASE OF MODEL DRUG FROM A NOVEL POLYACRYLIC ACID-POLYALUMINIUM CHLORIDE SUPERABSORBENT. IRANIAN POLYMER JOURNAL (ENGLISH), 19(7 (121)), 531-540. SID. https://sid.ir/paper/563987/en

    Vancouver: Copy

    CHEN Y., LIANG Y., CHEN M.N., GUO Y.W., YE Y.CH., TAN H.M.. A SUSTAINED RELEASE OF MODEL DRUG FROM A NOVEL POLYACRYLIC ACID-POLYALUMINIUM CHLORIDE SUPERABSORBENT. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2010;19(7 (121)):531-540. Available from: https://sid.ir/paper/563987/en

    IEEE: Copy

    Y. CHEN, Y. LIANG, M.N. CHEN, Y.W. GUO, Y.CH. YE, and H.M. TAN, “A SUSTAINED RELEASE OF MODEL DRUG FROM A NOVEL POLYACRYLIC ACID-POLYALUMINIUM CHLORIDE SUPERABSORBENT,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 19, no. 7 (121), pp. 531–540, 2010, [Online]. Available: https://sid.ir/paper/563987/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button