DAPSONE AS AN ALTERNATIVE THERAPY IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER

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SALEHZADEH FARHAD; JAHANGIRI SEPIDEH; MOHAMMADI ELNAZ

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Journal Paper

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Journal: Iranian Journal of Pediatrics Year:2012 | Volume:22 | Issue:1 Page(s): 23-27

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Title

DAPSONE AS AN ALTERNATIVE THERAPY IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER

Author(s)

SALEHZADEH FARHAD | JAHANGIRI SEPIDEH | MOHAMMADI ELNAZ | Issue Writer Certificate

Keywords

DAPSONE

FAMILIAL MEDITERRANAN FEVER

PERIODIC FEVER

CHILDREN

Abstract

Objective: FAMILIAL MEDITERRANAN FEVER is an hereditary autoinflammatory disease that presents with recurrent febrile attacks and poly serositis. Colchicine is the only known treatment in this diease. However, nearly 5-10% of patients are resistant to colchicines. There are many different modalities in colchicine resistant patients, biologic and immunosupressive drugs being the known ones. We studied the efficacy of DAPSONE as an anti-inflammatory drug in CHILDREN with FMF who did not tolerate colchicine well.Methods: This is a case series study in 10 patients who had FMF on the base of Tel-Hashomer criteria and did not tolerate colchicine or did not respond to it well. Patients took 2mg/kg DAPSONE in single dose, during 6 months.FindingsIn four patients episodic attacks returned after 27 days, so the drug was discontinued. One patient refused to continue the study; in five patients DAPSONE was taken in average for 8 months and 6 days, at least for 6 months. These five patients had no episodes of attack during the following observation.Conclusion: DAPSONE could control episodic attacks of FMF in 50% of cases. It might be considered as an alternative therapy in FMF cases not responding to colchicine.

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APA: Copy

SALEHZADEH, FARHAD, JAHANGIRI, SEPIDEH, & MOHAMMADI, ELNAZ. (2012). DAPSONE AS AN ALTERNATIVE THERAPY IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER. IRANIAN JOURNAL OF PEDIATRICS, 22(1), 23-27. SID. https://sid.ir/paper/566688/en

Vancouver: Copy

SALEHZADEH FARHAD, JAHANGIRI SEPIDEH, MOHAMMADI ELNAZ. DAPSONE AS AN ALTERNATIVE THERAPY IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER. IRANIAN JOURNAL OF PEDIATRICS[Internet]. 2012;22(1):23-27. Available from: https://sid.ir/paper/566688/en

IEEE: Copy

FARHAD SALEHZADEH, SEPIDEH JAHANGIRI, and ELNAZ MOHAMMADI, “DAPSONE AS AN ALTERNATIVE THERAPY IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER,” IRANIAN JOURNAL OF PEDIATRICS, vol. 22, no. 1, pp. 23–27, 2012, [Online]. Available: https://sid.ir/paper/566688/en

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