REFORMULATION OF COTRIMAXAZOLS SUSPENSION

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GHARAVI SEYED MANOUCHEHR; VAFAEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Yafteh Year:2001 | Volume:2 | Issue:6-7 Page(s): 25-31

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Information Journal Paper

Title

REFORMULATION OF COTRIMAXAZOLS SUSPENSION

Author(s)

GHARAVI SEYED MANOUCHEHR | VAFAEI M. | Issue Writer Certificate

Keywords

REFORMULATION

SUSPENSIOP

COTRIMAXAZOLE

Abstract

The direct relation between physical stability of oral COTRIMAXAZOLE’s suspension and Consumed dose in each time is considerable.To implement this research, different tests carried out including: measurements of PH microscopic observation, reologic characteristics and degree of flocculation.Results showed that polymers like microclystalline cellulose and P.E.G each of them individually encouraged crystal growth, but blend of P.E.G and P.V.P behaved differently in addition modified viscosity of the suspension.It is necessary for COTRIMAXAZOLE’s suspension to be converted from a deflocculated to flocculated state by using polymers. A blend of P.V.P and P.E.G exerted their effect by entrapping the COTRIMAXAZOLE particles in their gell like network. This encouraged formation of bridge between adjacent particles, but the whole surface of the solid was not coated, so that cross liking occurred on storage, besides no crystal growth was see consequently ,flocculated suspension sediments rapidly, but it will be homogenized shaking.

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APA: Copy

GHARAVI, SEYED MANOUCHEHR, & VAFAEI, M.. (2001). REFORMULATION OF COTRIMAXAZOLS SUSPENSION. YAFTEH, 2(6-7), 25-31. SID. https://sid.ir/paper/567650/en

Vancouver: Copy

GHARAVI SEYED MANOUCHEHR, VAFAEI M.. REFORMULATION OF COTRIMAXAZOLS SUSPENSION. YAFTEH[Internet]. 2001;2(6-7):25-31. Available from: https://sid.ir/paper/567650/en

IEEE: Copy

SEYED MANOUCHEHR GHARAVI, and M. VAFAEI, “REFORMULATION OF COTRIMAXAZOLS SUSPENSION,” YAFTEH, vol. 2, no. 6-7, pp. 25–31, 2001, [Online]. Available: https://sid.ir/paper/567650/en

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