INCREASED EXPRESSION OF PPARY1 IN THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS INTO DEFINITIVE ENDODERM

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SHABANI KHADIJEH; GHAEDI KAMRAN; TANHAEI SOMAYEH; KARBALAIE KHADIJEH; SALAMIAN AHMAD; RABIEE FARZANEH; FARROKHI ALI; NASRESFAHANI MOHAMMAD HOSSEIN; BAHARVAND HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:9 | Issue:3 Page(s): 2530-2533

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Title

INCREASED EXPRESSION OF PPARY1 IN THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS INTO DEFINITIVE ENDODERM

Author(s)

Keywords

PPAR GAMMA

STEM CELLS

DEFINITIVE ENDODERM

CELL DIFFERENTIATION

Abstract

Peroxisome Proliferator-Activated Receptor g (PPARg) belongs to the nuclear receptor dependent ligand-activated transcription factors that regulates expression of many genes involved in metabolism, CELL DIFFERENTIATION, adipogenesis, inflammation and apoptosis. Despite numerous studies which have been published on PPARg activation during ectodermal differentiation, there are a limited number of studies on the role of PPARg in endodermal differentiation. Thus, the aim of this study was to assess the expression of PPARg during in vitro differentiation of mouse embryonic STEM CELLS (mESCs) into DEFINITIVE ENDODERM (DE). In this study we demonstrated that an increase of PPARg expression profile occurred upon retinoic acid (RA) treatment in the process of differentiation. This may arise from a possible role of PPARg in the process of endodermal differentiation which should be clarified in further studies.

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APA: Copy

SHABANI, KHADIJEH, GHAEDI, KAMRAN, TANHAEI, SOMAYEH, KARBALAIE, KHADIJEH, SALAMIAN, AHMAD, RABIEE, FARZANEH, FARROKHI, ALI, NASRESFAHANI, MOHAMMAD HOSSEIN, & BAHARVAND, HOSSEIN. (2011). INCREASED EXPRESSION OF PPARY1 IN THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS INTO DEFINITIVE ENDODERM. GENETICS IN THE 3RD MILLENNIUM, 9(3), 2530-2533. SID. https://sid.ir/paper/570976/en

Vancouver: Copy

SHABANI KHADIJEH, GHAEDI KAMRAN, TANHAEI SOMAYEH, KARBALAIE KHADIJEH, SALAMIAN AHMAD, RABIEE FARZANEH, FARROKHI ALI, NASRESFAHANI MOHAMMAD HOSSEIN, BAHARVAND HOSSEIN. INCREASED EXPRESSION OF PPARY1 IN THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS INTO DEFINITIVE ENDODERM. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;9(3):2530-2533. Available from: https://sid.ir/paper/570976/en

IEEE: Copy

KHADIJEH SHABANI, KAMRAN GHAEDI, SOMAYEH TANHAEI, KHADIJEH KARBALAIE, AHMAD SALAMIAN, FARZANEH RABIEE, ALI FARROKHI, MOHAMMAD HOSSEIN NASRESFAHANI, and HOSSEIN BAHARVAND, “INCREASED EXPRESSION OF PPARY1 IN THE DIFFERENTIATION OF MOUSE EMBRYONIC STEM CELLS INTO DEFINITIVE ENDODERM,” GENETICS IN THE 3RD MILLENNIUM, vol. 9, no. 3, pp. 2530–2533, 2011, [Online]. Available: https://sid.ir/paper/570976/en

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