ENALAPRIL IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH MIGRAINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAGHJOOY JAVANMARD SHAGHAYEGH; SONBOLESTAN SEYED ALI; HESHMAT GHAHDARIJANI KIAN; SAADATNIA MOHAMAD; SONBOLESTAN SEYED AHMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2011 | Volume:16 | Issue:1 Page(s): 26-32

Download Full-Text

View:

348

Download:

188

Cites:

Information Journal Paper

Title

ENALAPRIL IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH MIGRAINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Author(s)

Keywords

ENDOTHELIUM

MIGRAINE DISORDERS

NITRITES

C-REACTIVE PROTEIN

Abstract

BACKGROUND: There are increasing evidences of endothelial dysfunction in migraine. The ACE-inhibitors have previously been shown to be effective in migraine prophylaxis. Furthermore, ACE inhibitors have beneficial effects on endothelial dysfunction. We therefore investigated whether Enalapril is effective in endothelial function improvement.METHODS: In this randomized clinical trial, 10 mg Enalapril daily was compared with matched placebo in 40 patients with migraine for two months. Flow Mediated Dilation (FMD), serum total nitrite and C-REACTIVE PROTEIN (CRP) were measured in all patients at the baseline and after 2 months.RESULTS: Patients' FMD increased in the case group after treatment with Enalapril (p=0.002) while there was no significant change in control group. Total nitrite concentration increased in case group (p=0.000), while there was no significant difference before treatment. There was no significant difference in the CRP concentrations in two groups.CONCLUSIONS: These results indicate that ACE inhibition can improve endothelial function in patients with migraine, as it has been shown by both FMD and serum levels of nitric oxide. The mechanism could be either that Enalapril limits the angiotensin II-induced production of superoxide radicals which would normally inactivate nitric oxide, or that it may increase bradykinin-mediated nitric oxide release.

Cites

No record.

References

No record.

Cite

APA: Copy

HAGHJOOY JAVANMARD, SHAGHAYEGH, SONBOLESTAN, SEYED ALI, HESHMAT GHAHDARIJANI, KIAN, SAADATNIA, MOHAMAD, & SONBOLESTAN, SEYED AHMAD. (2011). ENALAPRIL IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH MIGRAINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 16(1), 26-32. SID. https://sid.ir/paper/571825/en

Vancouver: Copy

HAGHJOOY JAVANMARD SHAGHAYEGH, SONBOLESTAN SEYED ALI, HESHMAT GHAHDARIJANI KIAN, SAADATNIA MOHAMAD, SONBOLESTAN SEYED AHMAD. ENALAPRIL IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH MIGRAINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2011;16(1):26-32. Available from: https://sid.ir/paper/571825/en

IEEE: Copy

SHAGHAYEGH HAGHJOOY JAVANMARD, SEYED ALI SONBOLESTAN, KIAN HESHMAT GHAHDARIJANI, MOHAMAD SAADATNIA, and SEYED AHMAD SONBOLESTAN, “ENALAPRIL IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH MIGRAINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 16, no. 1, pp. 26–32, 2011, [Online]. Available: https://sid.ir/paper/571825/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops