POLYMORPHISMS WITHIN EXON 9, BUT NOT INTRON 8, OF THE VITAMIN D RECEPTOR GENE ARE ASSOCIATED WITH ASTHMA

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KAZEMI ARABABADI MOHAMMAD; ABOUSAIDI HAMID; HASSANSHAHI GHOLAMHOSSEIN; POURFATHOLLAH ALI AKBAR; DANESHMANDI SAEED; AKBARPOUR VAJIHE; HAKIMI HAMID; KENNEDY DEREK

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Journal: Iranian Journal of Basic Medical Sciences Year:2011 | Volume:14 | Issue:3 (50) Page(s): 225-230

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Title

POLYMORPHISMS WITHIN EXON 9, BUT NOT INTRON 8, OF THE VITAMIN D RECEPTOR GENE ARE ASSOCIATED WITH ASTHMA

Author(s)

Keywords

ASTHMA

POLYMORPHISM

VDR

Abstract

Objective(s): Deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of ASTHMA. Vitamin D3 and its nuclear receptor appear to be factors that maybe involved in regulating I mmune responses during the progression of ASTHMA. The aim of this study was to investigate the association between POLYMORPHISMs in intron 8 and exon 9 of the vitamin D receptor (VDR) and this disease.Materials and Methods This study was performed on 100 ASTHMAtic patients and 100 healthy controls. PCR-RFLP was performed to examine POLYMORPHISMs in intron 8 and exon 9 of VDR gene.Results Our results showed a statistically significant difference in the Taq-1 evaluated genotypes of exon 9 of the VDR gene when comparing healthy patients to ASTHMAtic patients.Conclusion Based on our results, it can be concluded that VDR and its functional POLYMORPHISMs may play an important role in the pathogenesis of ASTHMA.

Cites

ASSOCIATION BETWEEN VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM AND BONE MINERAL DENSITY IN A POPULATION OF 146 IRANIAN WOMEN

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APA: Copy

KAZEMI ARABABADI, MOHAMMAD, ABOUSAIDI, HAMID, HASSANSHAHI, GHOLAMHOSSEIN, POURFATHOLLAH, ALI AKBAR, DANESHMANDI, SAEED, AKBARPOUR, VAJIHE, HAKIMI, HAMID, & KENNEDY, DEREK. (2011). POLYMORPHISMS WITHIN EXON 9, BUT NOT INTRON 8, OF THE VITAMIN D RECEPTOR GENE ARE ASSOCIATED WITH ASTHMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 14(3 (50)), 225-230. SID. https://sid.ir/paper/572640/en

Vancouver: Copy

KAZEMI ARABABADI MOHAMMAD, ABOUSAIDI HAMID, HASSANSHAHI GHOLAMHOSSEIN, POURFATHOLLAH ALI AKBAR, DANESHMANDI SAEED, AKBARPOUR VAJIHE, HAKIMI HAMID, KENNEDY DEREK. POLYMORPHISMS WITHIN EXON 9, BUT NOT INTRON 8, OF THE VITAMIN D RECEPTOR GENE ARE ASSOCIATED WITH ASTHMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2011;14(3 (50)):225-230. Available from: https://sid.ir/paper/572640/en

IEEE: Copy

MOHAMMAD KAZEMI ARABABADI, HAMID ABOUSAIDI, GHOLAMHOSSEIN HASSANSHAHI, ALI AKBAR POURFATHOLLAH, SAEED DANESHMANDI, VAJIHE AKBARPOUR, HAMID HAKIMI, and DEREK KENNEDY, “POLYMORPHISMS WITHIN EXON 9, BUT NOT INTRON 8, OF THE VITAMIN D RECEPTOR GENE ARE ASSOCIATED WITH ASTHMA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 14, no. 3 (50), pp. 225–230, 2011, [Online]. Available: https://sid.ir/paper/572640/en

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