مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PRODUCTION AND QUALITY CONTROL OF 166HO-CHITOSANFOR THERAPEUTIC APPLICATIONS

Pages

  1-8

Abstract

 Introduction: In this research, [166Ho] Holmium CHITOSAN complex production is described in details, followed by determination of complex radiochemical purity, stability and BIODISTRIBUTION (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based CHITOSAN kit for ultimate RADIOSYNOVECTOMY as well as radiotherapy applications was developed.Methods: 166Ho-CHITOSAN complex was prepared using CHITOSAN concentrations and 166HoCl3 followed by intra-articular injection and BIODISTRIBUTION studies in wild-type rats including and excluding injected knee.Results: The [166Ho] Holmium CHITOSAN complex was prepared with high radiochemical yield (>95 %) in the optimized condition (35mg/3ml of CHITOSAN  in %1 AcOH, pH. 3, >98%, ITLC) was injected to wild-type rats followed by the BIODISTRIBUTION studies of the compound among the tissues excluding the injected knee data. Intra-articular injection of [166Ho] holmium CHITOSAN complex to male wild-type rats and investigation of leakage of activity in the body showed that most of injected dose has remained in injection site 144 h after injection. Conclusion: Successful development and formulation of 166Ho-CHITOSAN kit is described. This kit has the potential for use in clinical setting namely for RADIOSYNOVECTOMY and cancer radiochemotherapy.

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    APA: Copy

    ZOLGHADRI, SAMANEH, JALILIAN, AMIR REZA, YOUSEFNIA, HASSAN, BAHRAMI SAMANI, ALI, SHIRVANI ARANI, SIMINDOKHT, MAZIDI, MOHAMMAD, AKHLAGHI, MEHDI, & GHANNADI MARAGHEH, MOHAMMAD. (2010). PRODUCTION AND QUALITY CONTROL OF 166HO-CHITOSANFOR THERAPEUTIC APPLICATIONS. IRANIAN JOURNAL OF NUCLEAR MEDICINE, 18(2 (SERIAL NUMBER 34)), 1-8. SID. https://sid.ir/paper/572786/en

    Vancouver: Copy

    ZOLGHADRI SAMANEH, JALILIAN AMIR REZA, YOUSEFNIA HASSAN, BAHRAMI SAMANI ALI, SHIRVANI ARANI SIMINDOKHT, MAZIDI MOHAMMAD, AKHLAGHI MEHDI, GHANNADI MARAGHEH MOHAMMAD. PRODUCTION AND QUALITY CONTROL OF 166HO-CHITOSANFOR THERAPEUTIC APPLICATIONS. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2010;18(2 (SERIAL NUMBER 34)):1-8. Available from: https://sid.ir/paper/572786/en

    IEEE: Copy

    SAMANEH ZOLGHADRI, AMIR REZA JALILIAN, HASSAN YOUSEFNIA, ALI BAHRAMI SAMANI, SIMINDOKHT SHIRVANI ARANI, MOHAMMAD MAZIDI, MEHDI AKHLAGHI, and MOHAMMAD GHANNADI MARAGHEH, “PRODUCTION AND QUALITY CONTROL OF 166HO-CHITOSANFOR THERAPEUTIC APPLICATIONS,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 2 (SERIAL NUMBER 34), pp. 1–8, 2010, [Online]. Available: https://sid.ir/paper/572786/en

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