NEOPLASTIC BONE MARROW NICHE: HEMATOPOIETIC AND MESENCHYMAL STEM CELLS

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SAKI NAJMALDIN; ABROUN SAEID; FARSHDOUSTI HAGH MAJID; ASGHAREI FARAHNAZ

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Journal Paper

Paper Information

Journal: Cell Journal (Yakhteh) Year:2011 | Volume:13 | Issue:3 (51) Page(s): 131-136

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Information Journal Paper

Title

NEOPLASTIC BONE MARROW NICHE: HEMATOPOIETIC AND MESENCHYMAL STEM CELLS

Author(s)

SAKI NAJMALDIN | ABROUN SAEID | FARSHDOUSTI HAGH MAJID | ASGHAREI FARAHNAZ | Issue Writer Certificate

Keywords

NEOPLASTIC NICHE

STEM CELLS

BONE MARROW

CANCER

Abstract

The NEOPLASTIC NICHE comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. These niches are important for both the maintenance of CANCER STEM CELLS and the induction of neoplastic cells survival and proliferation. Each niche contains a population of tumor STEM CELLS supported by a closely associated vascular bed comprising mesenchyme- derived cells and extracellular matrix. Targeting CANCER STEM CELLS and NEOPLASTIC NICHE may provide new therapies to eradicate tumors. Much progress has been very recently made in the understanding of the cellular and molecular interactions in the microenvironment of NEOPLASTIC NICHEs. This review article provides an overview of the NEOPLASTIC NICHEs in the BONE MARROW. In addition to highlighting recent advances in the field, we will also discuss components of the niche and their signaling pathways.

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APA: Copy

SAKI, NAJMALDIN, ABROUN, SAEID, FARSHDOUSTI HAGH, MAJID, & ASGHAREI, FARAHNAZ. (2011). NEOPLASTIC BONE MARROW NICHE: HEMATOPOIETIC AND MESENCHYMAL STEM CELLS. CELL JOURNAL (YAKHTEH), 13(3 (51)), 131-136. SID. https://sid.ir/paper/574389/en

Vancouver: Copy

SAKI NAJMALDIN, ABROUN SAEID, FARSHDOUSTI HAGH MAJID, ASGHAREI FARAHNAZ. NEOPLASTIC BONE MARROW NICHE: HEMATOPOIETIC AND MESENCHYMAL STEM CELLS. CELL JOURNAL (YAKHTEH)[Internet]. 2011;13(3 (51)):131-136. Available from: https://sid.ir/paper/574389/en

IEEE: Copy

NAJMALDIN SAKI, SAEID ABROUN, MAJID FARSHDOUSTI HAGH, and FARAHNAZ ASGHAREI, “NEOPLASTIC BONE MARROW NICHE: HEMATOPOIETIC AND MESENCHYMAL STEM CELLS,” CELL JOURNAL (YAKHTEH), vol. 13, no. 3 (51), pp. 131–136, 2011, [Online]. Available: https://sid.ir/paper/574389/en

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