COMPARISON OF SPIRONOLACTONE PLUS CYPROTERONE ACETATE PLUS CYPROTERONE COMPOUND WITH
SPIRONOLACTONE PLUS CYPROTERONE COMPOUND IN HIRSUTISM: A RANDOMIZED CLINICAL TRIAL

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ANSARIN H.; MEHREGAN R.; HOSSEINI J.

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Journal: Iranian Journal of Dermatology Year:2004 | Volume:3 | Issue:3 (27) Page(s): 156-165

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Information Journal Paper

Title

COMPARISON OF SPIRONOLACTONE PLUS CYPROTERONE ACETATE PLUS CYPROTERONE COMPOUND WITH SPIRONOLACTONE PLUS CYPROTERONE COMPOUND IN HIRSUTISM: A RANDOMIZED CLINICAL TRIAL

Author(s)

ANSARIN H. | MEHREGAN R. | HOSSEINI J. | Issue Writer Certificate

Keywords

HIRSUTISMQ3

SPIRONOLACTONEQ4

CYPROTERONE ACETATEQ4

CYPROTERONE COMPOUNDQ4

Abstract

Background: Monotherapy is not usually effective in the treatment of HIRSUTISM. Objective: Comparison of two therapeutic regimens in the treatment of HIRSUTISM. Patients and Methods: In this open parallel controlled clinical trial, 101 patients suffering from HIRSUTISM were randomly divided into two equal groups. Fifty patients were treated with SPIRONOLACTONE ( 50 mg /day) plus CYPROTERONE COMPOUND (from 5th to 26th day of menstrual cycle) and the other group (51 patients) received CYPROTERONE ACETATE 50 mg /day (from 5thto 14thday of menstrual cycle) in addition to the above mentioned drugs for 6 months. The serum level of sex hormones and HIRSUTISM score (Ferriman-Gallway) were determined before and after treatment. T-test, chi-2 test and linear regression analysis were used for data analysis. Results: Mean HIRSUTISM score was 22/12±0/34 in first group and 22/15±0/34 in second groups before treatment. HIRSUTISM score was reduced to 12/74± 0/32 after treatment with 3 drugs and reduced to 16/73± 0/35 after treatment with two drugs. This reduction was significantly more in the first group after adjustment for other confounding variables (P<0/001). Conclusion: These two therapeutic regimens were both effective in the treatment of HIRSUTISM without serious hepatic, renal and metobolic side effects. Treatment with 3 antiandrogen drugs was more effective in reduction of HIRSUTISM scores.

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APA: Copy

ANSARIN, H., MEHREGAN, R., & HOSSEINI, J.. (2004). COMPARISON OF SPIRONOLACTONE PLUS CYPROTERONE ACETATE PLUS CYPROTERONE COMPOUND WITH SPIRONOLACTONE PLUS CYPROTERONE COMPOUND IN HIRSUTISM: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY, 3(3 (27)), 156-165. SID. https://sid.ir/paper/57654/en

Vancouver: Copy

ANSARIN H., MEHREGAN R., HOSSEINI J.. COMPARISON OF SPIRONOLACTONE PLUS CYPROTERONE ACETATE PLUS CYPROTERONE COMPOUND WITH SPIRONOLACTONE PLUS CYPROTERONE COMPOUND IN HIRSUTISM: A RANDOMIZED CLINICAL TRIAL. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2004;3(3 (27)):156-165. Available from: https://sid.ir/paper/57654/en

IEEE: Copy

H. ANSARIN, R. MEHREGAN, and J. HOSSEINI, “COMPARISON OF SPIRONOLACTONE PLUS CYPROTERONE ACETATE PLUS CYPROTERONE COMPOUND WITH SPIRONOLACTONE PLUS CYPROTERONE COMPOUND IN HIRSUTISM: A RANDOMIZED CLINICAL TRIAL,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 3, no. 3 (27), pp. 156–165, 2004, [Online]. Available: https://sid.ir/paper/57654/en

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