COMBINATION CHEMOTHERAPY WITH METHOTREXATE, FLUOROURACIL AND LEUCOVORIN IN ADVANCED MYCOSIS
FUNGOIDES

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SHAHIDI DADRAS M.; ATAEI L.

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Journal Paper

Paper Information

Journal: Iranian Journal of Dermatology Year:2001 | Volume:4 | Issue:2 (14) Page(s): 21-25

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Information Journal Paper

Title

COMBINATION CHEMOTHERAPY WITH METHOTREXATE, FLUOROURACIL AND LEUCOVORIN IN ADVANCED MYCOSIS FUNGOIDES

Author(s)

SHAHIDI DADRAS M. | ATAEI L. | Issue Writer Certificate

Keywords

SKIN LYMPHOMAQ4

CHEMOTHERAPYQ4

MYCOSIS FUNGOIDESQ4

Abstract

Background: MYCOSIS FUNGOIDES (MF) is a cutaneous T cell lymphoma. There are only palliative treatments in advanced stages with no cure. Most CHEMOTHERAPY regimens have temporary effects with various side effects. Objective: The objective of this study was to assess the efficacy of a new CHEMOTHERAPY regimen in advanced stages of MF. This regimen takes advantage of synergistic effect of methotrexate and fluorouracil and also uses leucovorin reduce to side effects of methotrexate. Patients & Methods: Five patients with advanced stages of MF (stage IIB and higher) were treated with several courses of this CHEMOTHERAPY regimen in a quasi-experimental study. Results: Four patients responded partially and one responded completely to this regimen but all of them relapsed after tapering the treatment. All of them tolerated the drugs well and no serious side effects were observed. Tumoral lesions showed better response. Conclusion: Although this CHEMOTHERAPY regimen, similar to other regimens, only had temporary and palliative effects, it was tolerated well without serious side effects.

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APA: Copy

SHAHIDI DADRAS, M., & ATAEI, L.. (2001). COMBINATION CHEMOTHERAPY WITH METHOTREXATE, FLUOROURACIL AND LEUCOVORIN IN ADVANCED MYCOSIS FUNGOIDES. IRANIAN JOURNAL OF DERMATOLOGY, 4(2 (14)), 21-25. SID. https://sid.ir/paper/57799/en

Vancouver: Copy

SHAHIDI DADRAS M., ATAEI L.. COMBINATION CHEMOTHERAPY WITH METHOTREXATE, FLUOROURACIL AND LEUCOVORIN IN ADVANCED MYCOSIS FUNGOIDES. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2001;4(2 (14)):21-25. Available from: https://sid.ir/paper/57799/en

IEEE: Copy

M. SHAHIDI DADRAS, and L. ATAEI, “COMBINATION CHEMOTHERAPY WITH METHOTREXATE, FLUOROURACIL AND LEUCOVORIN IN ADVANCED MYCOSIS FUNGOIDES,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 4, no. 2 (14), pp. 21–25, 2001, [Online]. Available: https://sid.ir/paper/57799/en

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