COMPOSITE HYDROGEL BEADS BASED ON CHITOSAN AND LAPONITE: PREPARATION, SWELLING, AND DRUG RELEASE BEHAVIOUR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

YANG HUIXIA; HUA SHUIBO; WANG WENBO; WANG AIQIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2011 | Volume:20 | Issue:6 (132) Page(s): 479-490

Download Full-Text

View:

753

Download:

630

Cites:

Information Journal Paper

Title

COMPOSITE HYDROGEL BEADS BASED ON CHITOSAN AND LAPONITE: PREPARATION, SWELLING, AND DRUG RELEASE BEHAVIOUR

Author(s)

YANG HUIXIA | HUA SHUIBO | WANG WENBO | WANG AIQIN | Issue Writer Certificate

Keywords

CHITOSAN

LAPONITE

COMPOSITE

DRUG RELEASE

OFLOXACIN

Abstract

Biopolymer/layered silicate COMPOSITEs have shown unique advantages and potentials for the passive targeting of drugs because they can overcome the burst drawbacks of organic carrier, increase the drug utilization and enhance the controllable capability of DRUG RELEASE. Furthermore, the biocompatibility and nontoxicity of biopolymers is retained, and therefore it is promising and applicable in pharmaceutical fields. The main research aim of this work was to develop a series of biopolymer/layered silicate COMPOSITE beads based on CHITOSAN (CTS) and LAPONITE (LA) by a simple ionic cross-linking reaction using sodium tripolyphosphate as the cross-linker. The resultant beads were characterized by Fourier transform infrared spectroscopy, scanning electronic microscope and X-ray diffraction analysis. The swelling behaviour in physiological pH solutions (7.4 and 1.2), drug encapsulation efficiency and controlled release behaviour were also investigated by using OFLOXACIN as the model drug to reveal the effects of introduced LA. The results indicate that the incorporation of LA remarkably improved the swelling behaviour, enhanced the drug entrapment efficiency, and slowed down the DRUG RELEASE behaviour in contrast to the pure organic CTS beads. The exfoliated LA clay could act as a physical cross-linker to facilitate the formation of network structure between the CTS and LA. It is suggested that LA may be developed as an effective additive for fabricating a sustained drug delivery system.

Cites

No record.

References

No record.

Cite

APA: Copy

YANG, HUIXIA, HUA, SHUIBO, WANG, WENBO, & WANG, AIQIN. (2011). COMPOSITE HYDROGEL BEADS BASED ON CHITOSAN AND LAPONITE: PREPARATION, SWELLING, AND DRUG RELEASE BEHAVIOUR. IRANIAN POLYMER JOURNAL (ENGLISH), 20(6 (132)), 479-490. SID. https://sid.ir/paper/578531/en

Vancouver: Copy

YANG HUIXIA, HUA SHUIBO, WANG WENBO, WANG AIQIN. COMPOSITE HYDROGEL BEADS BASED ON CHITOSAN AND LAPONITE: PREPARATION, SWELLING, AND DRUG RELEASE BEHAVIOUR. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2011;20(6 (132)):479-490. Available from: https://sid.ir/paper/578531/en

IEEE: Copy

HUIXIA YANG, SHUIBO HUA, WENBO WANG, and AIQIN WANG, “COMPOSITE HYDROGEL BEADS BASED ON CHITOSAN AND LAPONITE: PREPARATION, SWELLING, AND DRUG RELEASE BEHAVIOUR,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 20, no. 6 (132), pp. 479–490, 2011, [Online]. Available: https://sid.ir/paper/578531/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops