A COMPARISON BETWEEN THERAPEUTIC EFFECT OF TOPICAL SUCRALFATE AND TOPICAL TETRACYCLINE MOUTHWASH
SUSPENSION IN RECURRENT APHTHOUS STOMATITIS

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SHAHIDI DADRAS M.; NASEH GHAFOORI H.; GACHKAR L.

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Paper Information

Journal: Iranian Journal of Dermatology Year:2003 | Volume:6 | Issue:4 (24) Page(s): 3-10

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Title

A COMPARISON BETWEEN THERAPEUTIC EFFECT OF TOPICAL SUCRALFATE AND TOPICAL TETRACYCLINE MOUTHWASH SUSPENSION IN RECURRENT APHTHOUS STOMATITIS

Author(s)

SHAHIDI DADRAS M. | NASEH GHAFOORI H. | GACHKAR L. | Issue Writer Certificate

Keywords

RECURRENT APHTHOUS STOMATITISQ4

TETRACYCLINEQ4

SUCRALFATEQ4

Abstract

Background: The current treatments of RECURRENT APHTHOUS STOMATITIS are not very effective and are not justified for long term using due to their potential side effects. Objective: To compare the efficacy of topical SUCRALFATE mouthwash with topical TETRACYCLINE mouthwash in RECURRENT APHTHOUS STOMATITIS. Patients & Methods: In a randomized matched clinical trial, 60 patients with RECURRENT APHTHOUS STOMATITIS fulfilling our inclusion criteria, referred to skin clinics affiliated to Skin Research Center in Shahid Beheshti University of Medical Sciences in 1380-81 were assessed. The patients were randomly divided in two groups, matched for age and type of the ulcer. The case group (26 patients) used a mouthwash containing 1 gr SUCRALFATE per 15 cc, and the control group (34 patients) used a mouthwash containing 250 mg TETRACYCLINE per 15 cc, four times a day and were assessed every 2 weeks. The data were ana1yzed by chi-square and t-tests (P<0.05). Results: There was no significant difference between two groups regarding the frequency, healing time and pain of the aphthous lesions. Patients were more satisfied with the SUCRALFATE suspension than TETRACYCLINE suspension in the end of treatment period (P<0.03) and in the end of follow up period (P<0.04). No side effects were seen in two groups. Conclusion: SUCRALFATE suspension mouth wash can be considered equally effective as TETRACYCLINE mouthwash in treating RECURRENT APHTHOUS STOMATITIS. It can be considered as a special modality for aphthous ulcer treatment due to lack of systemic toxicity and side effects even if accidentally swallowed or absorbed through mucosal surfaces.

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APA: Copy

SHAHIDI DADRAS, M., NASEH GHAFOORI, H., & GACHKAR, L.. (2003). A COMPARISON BETWEEN THERAPEUTIC EFFECT OF TOPICAL SUCRALFATE AND TOPICAL TETRACYCLINE MOUTHWASH SUSPENSION IN RECURRENT APHTHOUS STOMATITIS. IRANIAN JOURNAL OF DERMATOLOGY, 6(4 (24)), 3-10. SID. https://sid.ir/paper/57888/en

Vancouver: Copy

SHAHIDI DADRAS M., NASEH GHAFOORI H., GACHKAR L.. A COMPARISON BETWEEN THERAPEUTIC EFFECT OF TOPICAL SUCRALFATE AND TOPICAL TETRACYCLINE MOUTHWASH SUSPENSION IN RECURRENT APHTHOUS STOMATITIS. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2003;6(4 (24)):3-10. Available from: https://sid.ir/paper/57888/en

IEEE: Copy

M. SHAHIDI DADRAS, H. NASEH GHAFOORI, and L. GACHKAR, “A COMPARISON BETWEEN THERAPEUTIC EFFECT OF TOPICAL SUCRALFATE AND TOPICAL TETRACYCLINE MOUTHWASH SUSPENSION IN RECURRENT APHTHOUS STOMATITIS,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 6, no. 4 (24), pp. 3–10, 2003, [Online]. Available: https://sid.ir/paper/57888/en

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