FIXED DRUG ERUPTION: A DESCRIPTIVE STUDY OF 100 CASES

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RASI A.; TAGHIZADEH A.R.

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Title

FIXED DRUG ERUPTION: A DESCRIPTIVE STUDY OF 100 CASES

Author(s)

RASI A. | TAGHIZADEH A.R. | Issue Writer Certificate

Keywords

DRUG ERUPTIONQ3

CO-TRIMOXAZOLEQ4

SULFONAMIDESQ4

Abstract

Background and Objective: Fixed DRUG ERUPTION (FDE) is one kind of drug rashes that is characterized by re-appearance of the lesions on the same sites after re-exposure to the causative drug. This study was performed to evaluate the epidemiologic characteristics of FDE. Materials and Methods: This descriptive study was done on a series of 100FDE cases, whom were admitted at the outpatient dermatology clinic of Hazrat-e-Rasoul Hospital over a six-year period. The primary diagnosis of FDE was suggested according to clinical findings including a remaining hyperpigmentation at the site of healed skin lesion(s). Oral challenge test with a single low dose administration of the suspected drug was used to confinn the diagnosis. Recurrence of the lesion(s) at the same body area(s) was considered as positive result. Results: Most commonly causative agents were CO-TRIMOXAZOLE and codein, which were found in 88% and 3% FDE cases; respectively. The most common site of involvement was penile glans in 57.7% of male patients and trunk in 48.3% of females. In one patient, reaction to multiple drugs including CO-TRIMOXAZOLE, codein and tetracycline was observed and after re-challenge with each drug, re-appearance of the skin lesion at the same site was evident. Several patients reported concomitant acetaminophen intake, but there was no reaction to that drug. Conclusion: CO-TRIMOXAZOLE is the most common cause of FDE.

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APA: Copy

RASI, A., & TAGHIZADEH, A.R.. (2005). FIXED DRUG ERUPTION: A DESCRIPTIVE STUDY OF 100 CASES. IRANIAN JOURNAL OF DERMATOLOGY, 8(5 (33)), 353-357. SID. https://sid.ir/paper/57930/en

Vancouver: Copy

RASI A., TAGHIZADEH A.R.. FIXED DRUG ERUPTION: A DESCRIPTIVE STUDY OF 100 CASES. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2005;8(5 (33)):353-357. Available from: https://sid.ir/paper/57930/en

IEEE: Copy

A. RASI, and A.R. TAGHIZADEH, “FIXED DRUG ERUPTION: A DESCRIPTIVE STUDY OF 100 CASES,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 8, no. 5 (33), pp. 353–357, 2005, [Online]. Available: https://sid.ir/paper/57930/en

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