SAFETY AND EFFICACY OF CAPSAICIN GEL IN PAINFUL AND PRURITIC DERMATOSES: POST-HERPETIC NEURALGIA, NOTALGIA PARESTHETICA, LICHEN SIMPLEX CHRONICUS

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ASILIAN A.; NILFOROOSHAN Z.

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Journal: Iranian Journal of Dermatology Year:2002 | Volume:5 | Issue:2 Page(s): 3-10

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Information Journal Paper

Title

SAFETY AND EFFICACY OF CAPSAICIN GEL IN PAINFUL AND PRURITIC DERMATOSES: POST-HERPETIC NEURALGIA, NOTALGIA PARESTHETICA, LICHEN SIMPLEX CHRONICUS

Author(s)

ASILIAN A. | NILFOROOSHAN Z. | Issue Writer Certificate

Keywords

CAPSAICINQ4

POSTHERPETIC NEURALGIAQ4

LICHEN SIMPLEX CHRONICUSQ3

NOTALGIA PARESTHETICAQ4

Abstract

Background: Pain and pruritus are two common symptoms in dermatology that are transmitted with unmyelinated C fibers via substance P. Topical CAPSAICIN is effective due to depletion of nerve endings from substance P. Objective: The efficacy and side effects of CAPSAICIN gel in painful and pruritic skin disorders was compared to placebo. Patients & Methods: In a controlled clinical trial, 40 patients (21 patients with POSTHERPETIC NEURALGIA, 10 with LICHEN SIMPLEX CHRONICUS, and 9 with NOTALGIA PARESTHETICA), with the mean age of 48 years were randomly treated with 0.075% CAPSAICIN gel or placebo q.i.d. for 4 weeks. The severity of symptoms and side effects were assessed every two weeks and recurrence was assessed also two months after treatment. Results: 31 cases (77%) completed their 4 weeks treatment period. According to Visual Analogue Score system, the mean of symptom severity decreased from 7.6 (±2.4) before treatment to 0.9 (±0.9) after treatment in CAPSAICIN group and decreased from 6.3 (±2.3) to 5.0 (P<0.05). (±3.2) in placebo group Conclusion: CAPSAICIN gel is effective in painful and pruritic skin disorders and has tolerable side effects..

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APA: Copy

ASILIAN, A., & NILFOROOSHAN, Z.. (2002). SAFETY AND EFFICACY OF CAPSAICIN GEL IN PAINFUL AND PRURITIC DERMATOSES: POST-HERPETIC NEURALGIA, NOTALGIA PARESTHETICA, LICHEN SIMPLEX CHRONICUS. IRANIAN JOURNAL OF DERMATOLOGY, 5(2), 3-10. SID. https://sid.ir/paper/57956/en

Vancouver: Copy

ASILIAN A., NILFOROOSHAN Z.. SAFETY AND EFFICACY OF CAPSAICIN GEL IN PAINFUL AND PRURITIC DERMATOSES: POST-HERPETIC NEURALGIA, NOTALGIA PARESTHETICA, LICHEN SIMPLEX CHRONICUS. IRANIAN JOURNAL OF DERMATOLOGY[Internet]. 2002;5(2):3-10. Available from: https://sid.ir/paper/57956/en

IEEE: Copy

A. ASILIAN, and Z. NILFOROOSHAN, “SAFETY AND EFFICACY OF CAPSAICIN GEL IN PAINFUL AND PRURITIC DERMATOSES: POST-HERPETIC NEURALGIA, NOTALGIA PARESTHETICA, LICHEN SIMPLEX CHRONICUS,” IRANIAN JOURNAL OF DERMATOLOGY, vol. 5, no. 2, pp. 3–10, 2002, [Online]. Available: https://sid.ir/paper/57956/en

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