DETECTION OF MUTATIONS IN EXONS 5-8 OF THE P53 GENE IN GASTRIC CANCER SAMPLES USING PCR-SSCP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, 2006-2007

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SAFAARI CHALESHTORI J.; MORADI M.T.; FAROKHI EFAT; TABATABAIEFAR M.A.; TAHERZADEH MARYAM; SHAYESTEH F.; MOBINI GH.R.; BANI TALEBI M.; MARDANI G.; SHAHRANI MEHRDAD; PARVIN NEDA; SHAHINFARD N.; RAHIMIAN GH.A.; NAZEM H.A.; HASHEMZADEH CHALESHTORI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2009 | Volume:11 | Issue:3 Page(s): 61-69

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Title

DETECTION OF MUTATIONS IN EXONS 5-8 OF THE P53 GENE IN GASTRIC CANCER SAMPLES USING PCR-SSCP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, 2006-2007

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Keywords

GASTRIC CANCERQ2

MUTATIONQ2

P53 GENEQ2

PCR-SSCPQ3

Abstract

Background and aim: GASTRIC CANCER is the second cause of cancer death world wide. Genetic factors including oncogens and tumor suppressor genes are always contributed in progression of this cancer. The P53 tumor suppressor gene has a broad role in the cell such as programmed cell death and stop cell replicating damaged DNA. MUTATIONs in the P53 GENE, which are frequently seen in human GASTRIC CANCER, impair its tumor suppression function. The aim of this study was to determine the P53 GENE MUTATIONs in GASTRIC CANCER specimens in Chaharmahal va Bakhtiari Province.Methods: In this descriptive-lab based study, we investigated the P53 GENE MUTATIONs in exons 5-8 in 38 paraffin embedded GASTRIC CANCER specimens. DNA was extracted following the standard phenol chloroform protocol. The P53 GENE MUTATIONs were determined using PCR-SSCP procedure.Results: Band shifts were detected in all positive controls examined. However, no shifted band was detected in samples from GASTRIC CANCER patients tested.Conclusion: The results of this study demonstrated that association between P53 GENE MUTATIONs and GASTRIC CANCER is very low in Chaharmahal va Bakhtiari province. However, we have examined a limited number of 38 gastric samples and more samples are needed to be investigated to unravel the contribution of P53 GENE MUTATIONs leading to GASTRIC CANCER in this province.

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APA: Copy

SAFAARI CHALESHTORI, J., MORADI, M.T., FAROKHI, EFAT, TABATABAIEFAR, M.A., TAHERZADEH, MARYAM, SHAYESTEH, F., MOBINI, GH.R., BANI TALEBI, M., MARDANI, G., SHAHRANI, MEHRDAD, PARVIN, NEDA, SHAHINFARD, N., RAHIMIAN, GH.A., NAZEM, H.A., & HASHEMZADEH CHALESHTORI, M.. (2009). DETECTION OF MUTATIONS IN EXONS 5-8 OF THE P53 GENE IN GASTRIC CANCER SAMPLES USING PCR-SSCP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, 2006-2007. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 11(3), 61-69. SID. https://sid.ir/paper/58099/en

Vancouver: Copy

SAFAARI CHALESHTORI J., MORADI M.T., FAROKHI EFAT, TABATABAIEFAR M.A., TAHERZADEH MARYAM, SHAYESTEH F., MOBINI GH.R., BANI TALEBI M., MARDANI G., SHAHRANI MEHRDAD, PARVIN NEDA, SHAHINFARD N., RAHIMIAN GH.A., NAZEM H.A., HASHEMZADEH CHALESHTORI M.. DETECTION OF MUTATIONS IN EXONS 5-8 OF THE P53 GENE IN GASTRIC CANCER SAMPLES USING PCR-SSCP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, 2006-2007. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;11(3):61-69. Available from: https://sid.ir/paper/58099/en

IEEE: Copy

J. SAFAARI CHALESHTORI, M.T. MORADI, EFAT FAROKHI, M.A. TABATABAIEFAR, MARYAM TAHERZADEH, F. SHAYESTEH, GH.R. MOBINI, M. BANI TALEBI, G. MARDANI, MEHRDAD SHAHRANI, NEDA PARVIN, N. SHAHINFARD, GH.A. RAHIMIAN, H.A. NAZEM, and M. HASHEMZADEH CHALESHTORI, “DETECTION OF MUTATIONS IN EXONS 5-8 OF THE P53 GENE IN GASTRIC CANCER SAMPLES USING PCR-SSCP IN CHAHARMAHAL VA BAKHTIARI PROVINCE, 2006-2007,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 11, no. 3, pp. 61–69, 2009, [Online]. Available: https://sid.ir/paper/58099/en

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