LOW DOSE EFFECTS OF ETHANOL ON SUCKLING RATS: ENZYMES ACTIVITY, HISTOLOGICAL ALTERATIONS AND GROWTH PARAMETERS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ABBASI M.; NAMJOO A.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:6 Page(s): 54-64

Download Full-Text

Persian Verion

View:

681

Download:

Cites:

Information Journal Paper

Title

LOW DOSE EFFECTS OF ETHANOL ON SUCKLING RATS: ENZYMES ACTIVITY, HISTOLOGICAL ALTERATIONS AND GROWTH PARAMETERS

Author(s)

ABBASI M. | NAMJOO A.R. | Issue Writer Certificate

Keywords

ETHANOLQ2

LACTATIONQ2

NEUROTOXICITYQ2

SUCKLING RATSQ2

WISTAR RATQ2

Abstract

Background and aims: Lower concentration of ETHANOL can be transferred to fetus through the placenta and to newborn offspring through breast milk. This study aimed at investigating the effects of LACTATION exposure to ETHANOL on some biochemical and pathological alterations in brain, liver and kidney tissues of in suckling rat.Methods: In this experimental study 21 adult female WISTAR RATs were devided in 3 grous, 2 experimental and 1 control group, the experimental groups received tap water with 2 and 4 % ETHANOL v/v and control group only received tap water during LACTATION period. On day 25 after birth, 9 pup rats from each experimental group were anesthetized. Blood samples were collected, alanine amino transferase (ALT), gamma glutamyle transferase (GGT), aspartate amino transferase (AST), alkaline phosphatase (ALP), Lactate dehydrogenase (LDH), creatine kinase, Blood nitrogen urea (BUN) and Creatinine were determined according to routine laboratory method. Histopathological examination of the brain, liver and kidney were also performed. The data were analyzed using ANOVA and Dunnett tests.Results: Use of ETHANOL did not cause any significant difference in ALT, GGT, AST, ALP and BUN experimental groups in comparison with the control group (P>0.05). But LDH, creatine significantly increased in experimental groups received tap water with 4% ETHANOL v/v compared to the control group, respectively (P<0.05). In histopathologic study, mild injuries were observed in kidney, liver and brain tissues of offspring rat exposed to 4% ETHANOL v/v.Conclusion: Alcohol consumption during LACTATION period can result in irrecoverable harms offspring.

Cites

No record.

References

No record.

Cite

APA: Copy

ABBASI, M., & NAMJOO, A.R.. (2014). LOW DOSE EFFECTS OF ETHANOL ON SUCKLING RATS: ENZYMES ACTIVITY, HISTOLOGICAL ALTERATIONS AND GROWTH PARAMETERS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(6), 54-64. SID. https://sid.ir/paper/58143/en

Vancouver: Copy

ABBASI M., NAMJOO A.R.. LOW DOSE EFFECTS OF ETHANOL ON SUCKLING RATS: ENZYMES ACTIVITY, HISTOLOGICAL ALTERATIONS AND GROWTH PARAMETERS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(6):54-64. Available from: https://sid.ir/paper/58143/en

IEEE: Copy

M. ABBASI, and A.R. NAMJOO, “LOW DOSE EFFECTS OF ETHANOL ON SUCKLING RATS: ENZYMES ACTIVITY, HISTOLOGICAL ALTERATIONS AND GROWTH PARAMETERS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 6, pp. 54–64, 2014, [Online]. Available: https://sid.ir/paper/58143/en

Related Journal Papers