EXPRESSION LEVELS OF MRNA CYTOKINES OF IL-17 AND IL-23 IN EPITHELIALFIBER OF STOMACH INPATIENTS WITH HELICOBACTER PYLORI USING REAL-TIME PCR IN CHAHAR MAHAL AND BAKHTIARI PROVINCE

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BAGHERI N.; SALIMZADEH L.; AZADEGAN DEHKORDI F.; HASHEMZADEH M.; HEYDARI S.; RAHIMIAN R.; RAHIMIAN GH.; TAGHIKHANI A.; RAFIEIAN KOUPAEE M.; KHEIRI S.; SHIRZAD H.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:6 Page(s): 124-131

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Title

EXPRESSION LEVELS OF MRNA CYTOKINES OF IL-17 AND IL-23 IN EPITHELIALFIBER OF STOMACH INPATIENTS WITH HELICOBACTER PYLORI USING REAL-TIME PCR IN CHAHAR MAHAL AND BAKHTIARI PROVINCE

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Keywords

HELICOBACTER PYLORIQ2

INTERLEUKINQ3

REAL-TIME PCRQ2

Abstract

Background and aims: IL-17 and IL-23 play an important role in intestinal mucosal defense against certain infections IL-17 causes neutrophils absorption to the site of infection and it results in inflammation. In this study, IL-23 and IL-17 mRNA expression levels will be checked in gastritis patients with HELICOBACTER PYLORI infection and patients without infection by quantitative REAL-TIME PCR Method.Methods: In this a case – control study, 58 patients with gastritis with H. pylori infection and 50 patients who were free of infection, were biopsy through endoscopy. After extracting mRNA into cDNA, mRNA IL-17 and IL-23 expression levels in samples were measured by REAL-TIME PCR and cytokines expression were analyzed between infected and non infected groups using the Mann–Whitney test.Results: In this study, no significant relation was observed between IL-17 mRNA expression in patients with H. pylori gastritis and gastritis patients without infection (P=0.941). And also no significant correlation was observed between the expression levels of mRNA IL23 in patients with HELICOBACTER PYLORI gastritis and patients without infection (P=0.76) Conclusions: The results showed that expression level in IL-17 mRNA and IL-23 in patients with HELICOBACTER PYLORI gastritis compare with the patients without infection is not higher, so there is not a significant relationship between the two groups. Therefore it’s requiring to seek the role of other involved cytokines in appearing gastritis for evaluation the treatment program.

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APA: Copy

BAGHERI, N., SALIMZADEH, L., AZADEGAN DEHKORDI, F., HASHEMZADEH, M., HEYDARI, S., RAHIMIAN, R., RAHIMIAN, GH., TAGHIKHANI, A., RAFIEIAN KOUPAEE, M., KHEIRI, S., & SHIRZAD, H.. (2014). EXPRESSION LEVELS OF MRNA CYTOKINES OF IL-17 AND IL-23 IN EPITHELIALFIBER OF STOMACH INPATIENTS WITH HELICOBACTER PYLORI USING REAL-TIME PCR IN CHAHAR MAHAL AND BAKHTIARI PROVINCE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(6), 124-131. SID. https://sid.ir/paper/58146/en

Vancouver: Copy

BAGHERI N., SALIMZADEH L., AZADEGAN DEHKORDI F., HASHEMZADEH M., HEYDARI S., RAHIMIAN R., RAHIMIAN GH., TAGHIKHANI A., RAFIEIAN KOUPAEE M., KHEIRI S., SHIRZAD H.. EXPRESSION LEVELS OF MRNA CYTOKINES OF IL-17 AND IL-23 IN EPITHELIALFIBER OF STOMACH INPATIENTS WITH HELICOBACTER PYLORI USING REAL-TIME PCR IN CHAHAR MAHAL AND BAKHTIARI PROVINCE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(6):124-131. Available from: https://sid.ir/paper/58146/en

IEEE: Copy

N. BAGHERI, L. SALIMZADEH, F. AZADEGAN DEHKORDI, M. HASHEMZADEH, S. HEYDARI, R. RAHIMIAN, GH. RAHIMIAN, A. TAGHIKHANI, M. RAFIEIAN KOUPAEE, S. KHEIRI, and H. SHIRZAD, “EXPRESSION LEVELS OF MRNA CYTOKINES OF IL-17 AND IL-23 IN EPITHELIALFIBER OF STOMACH INPATIENTS WITH HELICOBACTER PYLORI USING REAL-TIME PCR IN CHAHAR MAHAL AND BAKHTIARI PROVINCE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 6, pp. 124–131, 2014, [Online]. Available: https://sid.ir/paper/58146/en

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