DESIGNING OF THE IBUPROFEN MUCOADHESIVE FILM FOR RELIEF THE ORAL PAIN AND INFLAMMATION

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BAHRI NAJAFI R.; YARI A.; TAVAKOLI N.; KESHVARI M.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:6 Page(s): 132-140

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Title

DESIGNING OF THE IBUPROFEN MUCOADHESIVE FILM FOR RELIEF THE ORAL PAIN AND INFLAMMATION

Author(s)

BAHRI NAJAFI R. | YARI A. | TAVAKOLI N. | KESHVARI M. | Issue Writer Certificate

Keywords

IBUPROFENQ2

INFLAMMATIONQ2

MUCOADHESIVE ORAL FILMQ2

PAINQ2

Abstract

Background and aim: Muccoadhesive formulations are the novel drug delivery systems that are available in the forms of tablets and films. Films with mucoadhesive properties could prolong the residence time on the mucosa and provide a high concentration gradient for passive drug permeation, leading to the improvement of drug absorption. The aim of this study was to provide a mucoadhesive drug delivery system for local delivery of IBUPROFEN for relief oral PAIN and INFLAMMATION through oral route.Methods: In this experimental study, films were prepared by casting method using various compositions of EUDRAGIT RL100, Sodium carboxy methyl cellulose (NaCMC) as polymer and Glycerin and Propylene glycol as plasticizer. Their pharmaceutics characteristics such as physical features, weight, diameter, the degree of adhesion, the rate of drug release and the strength of loading were evaluated. Statistical analysis was conducted using variance analysis and Tukey test in SPSS software.Results: There was no difference between the formulations speed release of IBUPROFEN. Using more than 1000 mg EUDRAGIT increase the viscosity of the system and reduce the appearance of pores and creation for films, but films made by pharmaceutics EUDRAGIT and NaCMC were more acceptable in terms of appearance and features.Conclusion: The best formulation with excellent adherence and proper speed up the release was for35 mg of IBUPROFEN and 200 mg NaCMC and 1500 mg EUDRAGIT which was selected due to high viscosity, adhesion strength and proper damping of drug release (4 hours).Therefore it appears that this formulation could be regarded for many patients.

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APA: Copy

BAHRI NAJAFI, R., YARI, A., TAVAKOLI, N., & KESHVARI, M.. (2014). DESIGNING OF THE IBUPROFEN MUCOADHESIVE FILM FOR RELIEF THE ORAL PAIN AND INFLAMMATION. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(6), 132-140. SID. https://sid.ir/paper/58149/en

Vancouver: Copy

BAHRI NAJAFI R., YARI A., TAVAKOLI N., KESHVARI M.. DESIGNING OF THE IBUPROFEN MUCOADHESIVE FILM FOR RELIEF THE ORAL PAIN AND INFLAMMATION. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(6):132-140. Available from: https://sid.ir/paper/58149/en

IEEE: Copy

R. BAHRI NAJAFI, A. YARI, N. TAVAKOLI, and M. KESHVARI, “DESIGNING OF THE IBUPROFEN MUCOADHESIVE FILM FOR RELIEF THE ORAL PAIN AND INFLAMMATION,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 6, pp. 132–140, 2014, [Online]. Available: https://sid.ir/paper/58149/en

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