SURVEY OF PROTECTION ROLE OF SELENIUM IN REDUCTION OF T-2 TOXIN EFFECT ON PHAGOCYTOSIS FUNCTION OF HUMAN NEUTROPHIL

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ALAVI S.A.; SALIMIAN J.; AREFPOUR M.A.; REYAZEPOR M.; POURSASAN N.; AZIZI JALILIAN F.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:6 Page(s): 167-174

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Title

SURVEY OF PROTECTION ROLE OF SELENIUM IN REDUCTION OF T-2 TOXIN EFFECT ON PHAGOCYTOSIS FUNCTION OF HUMAN NEUTROPHIL

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Keywords

T-2 TOXINQ2

PHAGOCYTOSIS FUNCTIONQ2

NEUTROPHILQ2

SELENIUMQ2

Abstract

Background and aims: T-2 mycotoxin belongs to Trichothecene family. This toxin has some severe effects on immune system cells. This study attempted to investigate the T-2 TOXIN influence on PHAGOCYTOSIS FUNCTION of human peripheral blood NEUTROPHIL and the protection role of SELENIUM on this process.Methods: In this experimental study, human peripheral blood NEUTROPHILs purified using dextran-phicol method. For determining PHAGOCYTOSIS FUNCTION of NEUTROPHILs, opsonized Candida albicans yeasts count was used. Then NEUTROPHIL PHAGOCYTOSIS FUNCTION in presence of several concentration of T-2 TOXIN was investigated and numerous SELENIUM concentrations on reduction of T-2 TOXIN effects were studied. Data were analized using ANOVA in Stata.Results: T-2 TOXIN in 100 mg/ml concentration affected on Candida killing function of NEUTROPHIL and reduced this function to half. SELENIUM in 100 ng/ml had the best effect and approved Candida killing function to 90%.Conclusion: This study shows that T-2 TOXIN causes reduction of PHAGOCYTOSIS FUNCTION of NEUTROPHIL and SELENIUM has protection role and can return phagocytosis activity to near normal state.

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APA: Copy

ALAVI, S.A., SALIMIAN, J., AREFPOUR, M.A., REYAZEPOR, M., POURSASAN, N., & AZIZI JALILIAN, F.. (2014). SURVEY OF PROTECTION ROLE OF SELENIUM IN REDUCTION OF T-2 TOXIN EFFECT ON PHAGOCYTOSIS FUNCTION OF HUMAN NEUTROPHIL. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(6), 167-174. SID. https://sid.ir/paper/58154/en

Vancouver: Copy

ALAVI S.A., SALIMIAN J., AREFPOUR M.A., REYAZEPOR M., POURSASAN N., AZIZI JALILIAN F.. SURVEY OF PROTECTION ROLE OF SELENIUM IN REDUCTION OF T-2 TOXIN EFFECT ON PHAGOCYTOSIS FUNCTION OF HUMAN NEUTROPHIL. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(6):167-174. Available from: https://sid.ir/paper/58154/en

IEEE: Copy

S.A. ALAVI, J. SALIMIAN, M.A. AREFPOUR, M. REYAZEPOR, N. POURSASAN, and F. AZIZI JALILIAN, “SURVEY OF PROTECTION ROLE OF SELENIUM IN REDUCTION OF T-2 TOXIN EFFECT ON PHAGOCYTOSIS FUNCTION OF HUMAN NEUTROPHIL,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 6, pp. 167–174, 2014, [Online]. Available: https://sid.ir/paper/58154/en

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