THE EFFECT OF IRON OXIDE NANOPARTICLES ON LIVER ENZYMES (ALT, AST AND ALP), THYROID HORMONES (T3 AND T4) AND TSH IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AFKHAMI ARDAKANI M.; SHIRBAND A.; GOLZADEH J.; ASADI SAMANI M.; LATIFI E.; KHEYLAPOUR M.; JAFARI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2013 | Volume:14 | Issue:6 Page(s): 82-88

Download Full-Text

Persian Verion

View:

1,497

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF IRON OXIDE NANOPARTICLES ON LIVER ENZYMES (ALT, AST AND ALP), THYROID HORMONES (T3 AND T4) AND TSH IN RATS

Author(s)

Keywords

IRON OXIDE NANOPARTICLESQ2

LIVER ENZYMEQ2

THYROID HORMONEQ2

TSHQ2

Abstract

Background and aims: IRON OXIDE NANOPARTICLES have been used as contrast agents in MRI and in thermal therapy for cancer cells. However, their adverse effects on human health have not been fully investigated. In this study the effect of IRON OXIDE NANOPARTICLES on lever enzymes (ALT, AST and ALP), THYROID HORMONEs (T3 and T4) and TSH in rats were investigated.Methods: In this experimental study, 28 male Wistar rats were divided into 4 groups. Three intervention groups received iron oxide nanoparticle (in 20m g/kg, 50 m g/kg and 150 m g/kg doses, dissolved in 1 ml of distilled water) and the control group received 1 ml of distilled water through gavage tube daily for fifteen consecutive days. Data were analyzed using ANOVA and Tukeys tests.Results: The serum levels of ALP, ALT and T4 in the group receiving the maximum dose (150 m g/kg) showed a higher increase compared with control group (P<0.05) Serum AST level in groups receiving the medium (50 m g/kg) and maximum (150 m g/kg) doses showed more increase compared with control group (P<0.05). Serum TSH level in the groups receiving 50 m g/kg and 150 m g/kg doses underwent more decrease compared with control group (P<0.05).Conclusion: The results of this study show that IRON OXIDE NANOPARTICLES have toxic effects on liver and thyroid gland in mice at high concentrations (150 m g/kg).

Cites

THE EFFECTS OF FE2O4ZN NANOPARTICLES ON THYROID HORMONES AND EVALUATION OF CHANGES TISSUE THYROID IN MALE RAT

References

No record.

Cite

APA: Copy

AFKHAMI ARDAKANI, M., SHIRBAND, A., GOLZADEH, J., ASADI SAMANI, M., LATIFI, E., KHEYLAPOUR, M., & JAFARI, N.. (2013). THE EFFECT OF IRON OXIDE NANOPARTICLES ON LIVER ENZYMES (ALT, AST AND ALP), THYROID HORMONES (T₃ AND T₄) AND TSH IN RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 14(6), 82-88. SID. https://sid.ir/paper/58261/en

Vancouver: Copy

AFKHAMI ARDAKANI M., SHIRBAND A., GOLZADEH J., ASADI SAMANI M., LATIFI E., KHEYLAPOUR M., JAFARI N.. THE EFFECT OF IRON OXIDE NANOPARTICLES ON LIVER ENZYMES (ALT, AST AND ALP), THYROID HORMONES (T₃ AND T₄) AND TSH IN RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;14(6):82-88. Available from: https://sid.ir/paper/58261/en

IEEE: Copy

M. AFKHAMI ARDAKANI, A. SHIRBAND, J. GOLZADEH, M. ASADI SAMANI, E. LATIFI, M. KHEYLAPOUR, and N. JAFARI, “THE EFFECT OF IRON OXIDE NANOPARTICLES ON LIVER ENZYMES (ALT, AST AND ALP), THYROID HORMONES (T₃ AND T₄) AND TSH IN RATS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 6, pp. 82–88, 2013, [Online]. Available: https://sid.ir/paper/58261/en

Related Journal Papers