PREVALENCE OF CONSTITUTIVE AND INDUCIBLE RESISTANCE TO CLINDAMYCIN IN STAPHYLOCOCCI ISOLATES FROM HAJAR AND KASHANI HOSPITALS IN SHAHREKORD, 2008

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NAFISI M.R.; SHARIATI LALEH; VALIDI M.; KARIMI ALI

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Journal: Journal of Shahrekord University of Medical Sciences Year:2010 | Volume:12 | Issue:1 Page(s): 13-20

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Title

PREVALENCE OF CONSTITUTIVE AND INDUCIBLE RESISTANCE TO CLINDAMYCIN IN STAPHYLOCOCCI ISOLATES FROM HAJAR AND KASHANI HOSPITALS IN SHAHREKORD, 2008

Author(s)

NAFISI M.R. | SHARIATI LALEH | VALIDI M. | KARIMI ALI | Issue Writer Certificate

Keywords

CLINDAMYCINQ3

CONSTITUTIVE RESISTANCEQ3

ERYTHROMYCINQ2

STAPHYLOCOCCUSQ2

INDUCIBLE RESISTANCEQ3

Abstract

Background and aim: Resistance to CLINDAMYCIN (CL) in STAPHYLOCOCCUS aureus is both constitutive and inducible. In the present study, the prevalence of the constitutive and INDUCIBLE RESISTANCE to CL was investigated by disk diffusion and double-disk diffusion (D-test) methods.Methods: This descriptive-analytical study was performed on 230 STAPHYLOCOCCUS isolates. D-test was carried out for all the isolates with resistant phenotype for ERYTHROMYCIN and susceptible phenotype for CL. 15mg ERYTHROMYCIN and 2 mg CL disks were placed on plate at a distance of 15 mm. The appearance of D-shaped zones around the strains was checked after proper incubation. Results: Of the 230 STAPHYLOCOCCUS isolates, 55.6% were susceptible to CL, 37.5% had constitutive and 5.2% had INDUCIBLE RESISTANCE to CL. The frequencies of constitutive and INDUCIBLE RESISTANCE for CL in methicillin-resistant STAPHYLOCOCCUS aureus (MRSA) isolates were 66% and 9%, respectively and the frequencies of constitutive and INDUCIBLE RESISTANCE for CL in methicillin-susceptible isolates (MSSA) were 15.4% and 2.3%, respectively. Statistical tests revealed the INDUCIBLE RESISTANCE in MRS isolates to be 4.2 times more frequent than that in MSS isolates. The INDUCIBLE RESISTANCE frequency was 10.8- fold in MRSA compared to MSSA isolates.Conclusion: The study results showed that the INDUCIBLE RESISTANCE should be determined by D- test in all methicillin-resistant STAPHYLOCOCCUS isolates and also STAPHYLOCOCCUS strains resistant to ERYTHROMYCIN and susceptible to CL.

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APA: Copy

NAFISI, M.R., SHARIATI, LALEH, VALIDI, M., & KARIMI, ALI. (2010). PREVALENCE OF CONSTITUTIVE AND INDUCIBLE RESISTANCE TO CLINDAMYCIN IN STAPHYLOCOCCI ISOLATES FROM HAJAR AND KASHANI HOSPITALS IN SHAHREKORD, 2008. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 12(1), 13-20. SID. https://sid.ir/paper/58296/en

Vancouver: Copy

NAFISI M.R., SHARIATI LALEH, VALIDI M., KARIMI ALI. PREVALENCE OF CONSTITUTIVE AND INDUCIBLE RESISTANCE TO CLINDAMYCIN IN STAPHYLOCOCCI ISOLATES FROM HAJAR AND KASHANI HOSPITALS IN SHAHREKORD, 2008. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;12(1):13-20. Available from: https://sid.ir/paper/58296/en

IEEE: Copy

M.R. NAFISI, LALEH SHARIATI, M. VALIDI, and ALI KARIMI, “PREVALENCE OF CONSTITUTIVE AND INDUCIBLE RESISTANCE TO CLINDAMYCIN IN STAPHYLOCOCCI ISOLATES FROM HAJAR AND KASHANI HOSPITALS IN SHAHREKORD, 2008,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 1, pp. 13–20, 2010, [Online]. Available: https://sid.ir/paper/58296/en

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