THE EFFECT OF ENDURANCE TRAINING ON THE LEVEL OF TISSUE IL-6 AND VEGF IN MICE WITH BREAST CANCER

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AMANI SHALAMZARI S.; AGHAALINEJAD H.; ALIZADEH SH.; KAZEMI A.R.; SAEI M.A.; MINAYI N.; SHOKROLAHI F.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:16 | Issue:2 Page(s): 10-21

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Title

THE EFFECT OF ENDURANCE TRAINING ON THE LEVEL OF TISSUE IL-6 AND VEGF IN MICE WITH BREAST CANCER

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Keywords

ESTROGEN RECEPTOR DEPENDENT CANCERQ2

ENDURANCE TRAININGQ1

IL-6Q2

VEGFQ2

Abstract

Background and aims: The sport exercises include a potential to prevent breast cancer. The aim of this study was assessing the prophylactic effect and adjuvant therapy of exercise on cytokines involved in angiogenesis in estrogen-dependent breast cancer.Methods: Thirty-two female Balb/C mice were randomly assigned in 4 groups. After orientation in the environment, two groups of mice performed continuous endurance exercise for 8 weeks, and then estrogen-dependent MC4L2 cancer cells were injected to them. After that, one group of each of trained and non-trained mice performed endurance exercise 5 days per week for 6 weeks. Tumor volume was measured by a digital caliper weekly. Finally, the mice were sacrificed; tumor tissue was removed. Tumor sample was homogenized and the level of IL-6 and VEGF were measured using ELISA.Results: There was a significant difference in the level of IL-6 and VEGF among the groups and tumor growth (p<0.001). The level mean of IL-6 and VEGF cytokines and tumor growth in groups performing endurance exercise after malignancy (RTE and ETE) was lower than groups not performing (ETR and RTR), (P<0.05).Conclusion: Due to reduction of the level of these cytokines in groups doing exercise before and after malignancy, exercise training is presumed to have adjuvant therapy in estrogen-receptor dependent tumors in addition to very effective prophylactic role.

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APA: Copy

AMANI SHALAMZARI, S., AGHAALINEJAD, H., ALIZADEH, SH., KAZEMI, A.R., SAEI, M.A., MINAYI, N., & SHOKROLAHI, F.. (2014). THE EFFECT OF ENDURANCE TRAINING ON THE LEVEL OF TISSUE IL-6 AND VEGF IN MICE WITH BREAST CANCER. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 16(2), 10-21. SID. https://sid.ir/paper/58375/en

Vancouver: Copy

AMANI SHALAMZARI S., AGHAALINEJAD H., ALIZADEH SH., KAZEMI A.R., SAEI M.A., MINAYI N., SHOKROLAHI F.. THE EFFECT OF ENDURANCE TRAINING ON THE LEVEL OF TISSUE IL-6 AND VEGF IN MICE WITH BREAST CANCER. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(2):10-21. Available from: https://sid.ir/paper/58375/en

IEEE: Copy

S. AMANI SHALAMZARI, H. AGHAALINEJAD, SH. ALIZADEH, A.R. KAZEMI, M.A. SAEI, N. MINAYI, and F. SHOKROLAHI, “THE EFFECT OF ENDURANCE TRAINING ON THE LEVEL OF TISSUE IL-6 AND VEGF IN MICE WITH BREAST CANCER,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 2, pp. 10–21, 2014, [Online]. Available: https://sid.ir/paper/58375/en

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