Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born

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Karbor n.; HOSSEINI S.E.; RANJBAR OMRANI GH.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2018 | Volume:20 | Issue:2 Page(s): 24-34

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Title

Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born

Author(s)

Karbor n. | HOSSEINI S.E. | RANJBAR OMRANI GH. | Issue Writer Certificate

Keywords

TestosteroneQ2

HomocysteineQ2

FemurQ3

HumerusQ3

PerinatalQ2

NeonatalQ1

Abstract

Background and aims: Homocysteine is an amino acid sulfur-containing that its amount under the effects of androgenic hormones changes. The aim of the current study was to study the prenatal and Neonatal effects of Testosterone on serum Homocysteine and growth of Femur and Humerus bones length and diameter of rats’ born by considering the Homocysteine effect on the growth of bone tissue. Methods: This experimental study has been performed on 256 born of 40 male and female rats which are divided in four groups: control (no treatment), sham (treatment with drugs), experimental Perinatal and Neonatal by dosing 600 μ g/kg in pregnancy and lactation periods under Testosterone treatment. Then, the different groups of both males and females’ born in the days 7, 14, 21 and maturation of Testosterone levels, Homocysteine, and length and diameter of Femur and Humerus bones were evaluated and the results obtained using SPSS-20 software, t-test, and ANOVA were analyzed. The significant differences of the data was considered at P<0. 05. Results: Analysis of the results showed that a significant increase in rats’ born treated with Testosterone in the serum levels of Homocysteine and Testosterone is observed (P<0. 05). However, in the male and female born on the 21st and during maturity, the significant reduction in the Femur and Humerus bones length and diameter was observed (P<0. 05). Conclusion: The results showed that injection of Testosterone during pregnancy and lactation causes increasing Testosterone levels and Homocysteine and decreasing in the length and diameter of Femur and Humerus bones is concluded.

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APA: Copy

Karbor, n., HOSSEINI, S.E., & RANJBAR OMRANI, GH.. (2018). Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 20(2 ), 24-34. SID. https://sid.ir/paper/58432/en

Vancouver: Copy

Karbor n., HOSSEINI S.E., RANJBAR OMRANI GH.. Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;20(2 ):24-34. Available from: https://sid.ir/paper/58432/en

IEEE: Copy

n. Karbor, S.E. HOSSEINI, and GH. RANJBAR OMRANI, “Perinatal and neonatal effects of androgens on plasma levels of testosterone, homocysteine, long bones length and diameter in male and female rats’ born,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 2 , pp. 24–34, 2018, [Online]. Available: https://sid.ir/paper/58432/en

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