CORRELATION BETWEEN EXPRESSION LEVELS OF IL-6 AND CAGA VIRULENCE FACTOR IN H. PYLORI-INFECTED PATIENTS

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RAHIMIAN GH.; BAGHERI N.; AZADEGAN DEHKORDI F.; RAHIMIAN R.; SHIRZAD H.

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Title

CORRELATION BETWEEN EXPRESSION LEVELS OF IL-6 AND CAGA VIRULENCE FACTOR IN H. PYLORI-INFECTED PATIENTS

Author(s)

Keywords

HELICOBACTER PYLORIQ3

IL-6Q2

CAG AQ1

GASTRITISQ3

Abstract

Background and aims: HELICOBACTER PYLORI (H. pylori) infection is associated with marked infiltration inflammatory cells such as neutrophil, macrophage and H. pylori-specific T and B cells to involved organs with infection. The molecular pathways that control H. pylori-associated inflammatory reaction are complex, but locally induced cytokines seem to play a role to maintaining the ongoing inflammation. The aim of this study was to evaluate IL-6 mRNA expression in the H. pylori-infected and uninfected gastric patients and detect its correlation with CAG A among H. pylori- infected patients.Methods: This study was a case – control research. Biopsies were collected from 58 H. pylori-infected patients and 44 uninfected. Then, IL-6 mRNA levels were measured by real-time PCR. Presence of CAG A virulence factor was evaluated using PCR. IL-6 mRNA expression in infected and non-infected groups and its relationship with CAG A virulence factor were analyzed using t-test.Results: The IL-6 mRNA expression levels were significantly higher in H. pylori patients than uninfected patients (P<0.05). There was no relationship between CAG A virulence factor in H. pylori-infected patients and IL-6 mRNA expression (P>0.05).Conclusions: Inflammation will cause an increase in the expression of IL-6 gene and it may be independent of CAG A virulence factor.

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APA: Copy

RAHIMIAN, GH., BAGHERI, N., AZADEGAN DEHKORDI, F., RAHIMIAN, R., & SHIRZAD, H.. (2015). CORRELATION BETWEEN EXPRESSION LEVELS OF IL-6 AND CAGA VIRULENCE FACTOR IN H. PYLORI-INFECTED PATIENTS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(4), 54-60. SID. https://sid.ir/paper/58536/en

Vancouver: Copy

RAHIMIAN GH., BAGHERI N., AZADEGAN DEHKORDI F., RAHIMIAN R., SHIRZAD H.. CORRELATION BETWEEN EXPRESSION LEVELS OF IL-6 AND CAGA VIRULENCE FACTOR IN H. PYLORI-INFECTED PATIENTS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(4):54-60. Available from: https://sid.ir/paper/58536/en

IEEE: Copy

GH. RAHIMIAN, N. BAGHERI, F. AZADEGAN DEHKORDI, R. RAHIMIAN, and H. SHIRZAD, “CORRELATION BETWEEN EXPRESSION LEVELS OF IL-6 AND CAGA VIRULENCE FACTOR IN H. PYLORI-INFECTED PATIENTS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 4, pp. 54–60, 2015, [Online]. Available: https://sid.ir/paper/58536/en

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