A SURVEY OF ACUTE HISTOPATHOLOGICAL EFFECTS OF SILVER NANOPARTICLES ON LIVER, KIDNEY WITH BLOOD CELLS DURING ORAL ADMINISTRATION IN MALE MICE (MUS MUSCULUS)

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JAFARZADEH SAMANI R.; HEYDARNEJAD M.S.; KABIRI SAMANI M.

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Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2015 | Volume:17 | Issue:4 Page(s): 97-107

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Title

A SURVEY OF ACUTE HISTOPATHOLOGICAL EFFECTS OF SILVER NANOPARTICLES ON LIVER, KIDNEY WITH BLOOD CELLS DURING ORAL ADMINISTRATION IN MALE MICE (MUS MUSCULUS)

Author(s)

JAFARZADEH SAMANI R. | HEYDARNEJAD M.S. | KABIRI SAMANI M. | Issue Writer Certificate

Keywords

NANOSILVERQ1

HISTOLOGYQ3

LIVER TISSUEQ1

KIDNEY TISSUEQ2

BLOOD CELLSQ3

Abstract

Background and aims: Nowadays, with increasing use of silver nanoparticles in various products including consumption and medical appliances, it is necessary to consider toxicity of these nanoparticles for their safety issues. This study was designed and performed to investigate the silver nanoparticles acute histopathological effects on liver, kidney with BLOOD CELLS during oral administration in male mice (Mus musculus).Methods: In this experimental study, a group of 45 male BALB/c mice (weighting 24.2±3.0 g) were randomly divided into three groups (two treatments and one control), each with 15 mice. Daily and at the same time, two silver nanoparticle groups were orally administered with 20 ppm and 50 ppm, but in control group, instead of silver nanopraticles, distilled water was used. Sampling was conducted on days 2, 7 and 14 of the experiment from the liver and kidney. With considering the BLOOD CELLS, Hematoxilin and Eosing (H& E) staining protocol was used to pathological study of the specimens.Results: The liver injuries were vacuolated of cytoplasm, degeneration and cell necrosis accompanied with focal accumulation of swelling cells and congestion. Glomerulonephritis, tubular cell necrosis, presence of swelling cells with congestion were observed in the kidney. The results showed that orally-administered silver nanoparticles at high dose of 50 ppm can cause damage to hepatic and renal tissues. There were no significant differences between red blood cell counts, hemoglobin and hematocrit (P>0.05). However, white blood cell counts were significantly higher in treated groups with silver nanoparticles (50 ppm) compared with the control (P<0.05).Conclusions: This study showed that liver and kidney are target organs for silver nanoparticles. Silver nanoparticles damage the mice’s liver and kidney, if eaten orally. Furthermore, orally-administered silver nanoparticles lead to considerable changes in white blood cell counts.

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APA: Copy

JAFARZADEH SAMANI, R., HEYDARNEJAD, M.S., & KABIRI SAMANI, M.. (2015). A SURVEY OF ACUTE HISTOPATHOLOGICAL EFFECTS OF SILVER NANOPARTICLES ON LIVER, KIDNEY WITH BLOOD CELLS DURING ORAL ADMINISTRATION IN MALE MICE (MUS MUSCULUS). JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(4), 97-107. SID. https://sid.ir/paper/58542/en

Vancouver: Copy

JAFARZADEH SAMANI R., HEYDARNEJAD M.S., KABIRI SAMANI M.. A SURVEY OF ACUTE HISTOPATHOLOGICAL EFFECTS OF SILVER NANOPARTICLES ON LIVER, KIDNEY WITH BLOOD CELLS DURING ORAL ADMINISTRATION IN MALE MICE (MUS MUSCULUS). JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(4):97-107. Available from: https://sid.ir/paper/58542/en

IEEE: Copy

R. JAFARZADEH SAMANI, M.S. HEYDARNEJAD, and M. KABIRI SAMANI, “A SURVEY OF ACUTE HISTOPATHOLOGICAL EFFECTS OF SILVER NANOPARTICLES ON LIVER, KIDNEY WITH BLOOD CELLS DURING ORAL ADMINISTRATION IN MALE MICE (MUS MUSCULUS),” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 4, pp. 97–107, 2015, [Online]. Available: https://sid.ir/paper/58542/en

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