PROTECTIVE EFFECT OF VITAMIN C AGAINST CHANGES CAUSED BY HEMOLYTIC ANEMIA IN SMALL INTESTINE HISTOARCHITECTURE OF PHENYLHYDRAZINE-TREATED MICE

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KANBARA H.; SHAHROOZ R.; SHALIZAR JALALI A.; RAZI M.; KALANTARI HESARI A.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2015 | Volume:17 | Issue:4 Page(s): 70-79

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Title

PROTECTIVE EFFECT OF VITAMIN C AGAINST CHANGES CAUSED BY HEMOLYTIC ANEMIA IN SMALL INTESTINE HISTOARCHITECTURE OF PHENYLHYDRAZINE-TREATED MICE

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Keywords

HEMOLYTIC ANEMIAQ2

PHENYLHYDRAZINEQ1

VITAMIN CQ2

SMALL INTESTINEQ2

MOUSEQ2

Abstract

Background and aims: HEMOLYTIC ANEMIA-induced hypoxia can lead to multi-organ dysfunctions. The present study was aimed to evaluate the efficacy of VITAMIN C as an antioxidant agent against HEMOLYTIC ANEMIA-induced changes in SMALL INTESTINE histoarchitecture of PHENYLHYDRAZINE (PHZ) treated mice.Methods: In this experimental study, adult male mice were randomly assigned to 4 groups of eight mice each. Both groups of mice received PHZ at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. One of these groups received VITAMIN C (250 mg/kg per day) intraperitoneally 4 hours before PHZ administration. A vehicle-treated control group and a VITAMIN C control group were also included.24 hours after the last treatment, desired segments of SMALL INTESTINEs were dissected out and provided histological processing. Then, morphometric parameters were evaluated.Results: PHZ caused a significant decrease in the villi width of duodenum and jejunum, crypts depth of duodenum, and distribution rate of the gobletcells in the ileal villi and height of villi in 3 segments of SMALL INTESTINE ((P<0.05). VITAMIN C markedly improved all changes in the aforementioned parameters.Conclusion: VITAMIN C could improve histological injuries caused by HEMOLYTIC ANEMIA in the mousse’s SMALL INTESTINE.

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APA: Copy

KANBARA, H., SHAHROOZ, R., SHALIZAR JALALI, A., RAZI, M., & KALANTARI HESARI, A.. (2015). PROTECTIVE EFFECT OF VITAMIN C AGAINST CHANGES CAUSED BY HEMOLYTIC ANEMIA IN SMALL INTESTINE HISTOARCHITECTURE OF PHENYLHYDRAZINE-TREATED MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(4), 70-79. SID. https://sid.ir/paper/58547/en

Vancouver: Copy

KANBARA H., SHAHROOZ R., SHALIZAR JALALI A., RAZI M., KALANTARI HESARI A.. PROTECTIVE EFFECT OF VITAMIN C AGAINST CHANGES CAUSED BY HEMOLYTIC ANEMIA IN SMALL INTESTINE HISTOARCHITECTURE OF PHENYLHYDRAZINE-TREATED MICE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;17(4):70-79. Available from: https://sid.ir/paper/58547/en

IEEE: Copy

H. KANBARA, R. SHAHROOZ, A. SHALIZAR JALALI, M. RAZI, and A. KALANTARI HESARI, “PROTECTIVE EFFECT OF VITAMIN C AGAINST CHANGES CAUSED BY HEMOLYTIC ANEMIA IN SMALL INTESTINE HISTOARCHITECTURE OF PHENYLHYDRAZINE-TREATED MICE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 4, pp. 70–79, 2015, [Online]. Available: https://sid.ir/paper/58547/en

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