THE EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE ON SERUM CONCENTRATION OF ESTEROGEN, PROGESTERONE, PROLACTIN AND GONADOTROPINS IN MATURE FEMALE RATS

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HOSSEINI E.; FROZANFAR M.; PAYEHDAR A.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:15 | Issue:5 Page(s): 12-21

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE ON SERUM CONCENTRATION OF ESTEROGEN, PROGESTERONE, PROLACTIN AND GONADOTROPINS IN MATURE FEMALE RATS

Author(s)

HOSSEINI E. | FROZANFAR M. | PAYEHDAR A. | Issue Writer Certificate

Keywords

ESTROGENQ2

PURSLANEQ2

PROGESTERONEQ2

PROLACTINQ3

GONADOTROPINQ2

RATQ2

Abstract

Background and aim: PURSLANE (Portulaca oleracea) has positive effects on total cholesterol reduction and has different effects on nerves system. Thus it might affect pituitary-gonadal axis.This study aimed to test the probable effects of hydroalcoholic extract of PURSLANE on GONADOTROPINs, estradiol, PROGESTERONE and PROLACTIN hormones.Methods: In this experimental study, 40 adult virgin female Vistar RATs strain weighing 189±2gr were divided in five groups of eights. The control group without any drug application, the sham groups received 0.2 ml distilled water as solvent and the experimental groups 1, 2 and 3 orally received 200, 400 and 800 mg/kg BW of hydroalcoholic extract of PURSLANE for 21 days. At the end of the period of 21 days, the blood test was taken and the amount of hormones in their blood was tested. The data were analyzed using one away ANOVA.Results: The findings of the study indicated a significant reduction (P<0.05) in the amount of estradiol in experimental group 3 and a reduction in the body weight in experimental group 2 compare with the both control and sham groups. No significant difference was observed in LH, FSH, PROGESTERONE and PROLACTIN.Conclusion: The results indicate the dose –dependent effect of PURSLANE in weight loss over 21 days. In addition, due to the anti-ESTROGENic and anti-aromatase compounds in PURSLANE, it reduces the concentration estradiol in the maximum dose. Thus, a prolonged application of PURSLANE may lead to hormone disorders and a reduction in fertility.

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APA: Copy

HOSSEINI, E., FROZANFAR, M., & PAYEHDAR, A.. (2014). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE ON SERUM CONCENTRATION OF ESTEROGEN, PROGESTERONE, PROLACTIN AND GONADOTROPINS IN MATURE FEMALE RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 15(5), 12-21. SID. https://sid.ir/paper/58581/en

Vancouver: Copy

HOSSEINI E., FROZANFAR M., PAYEHDAR A.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE ON SERUM CONCENTRATION OF ESTEROGEN, PROGESTERONE, PROLACTIN AND GONADOTROPINS IN MATURE FEMALE RATS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;15(5):12-21. Available from: https://sid.ir/paper/58581/en

IEEE: Copy

E. HOSSEINI, M. FROZANFAR, and A. PAYEHDAR, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF PURSLANE ON SERUM CONCENTRATION OF ESTEROGEN, PROGESTERONE, PROLACTIN AND GONADOTROPINS IN MATURE FEMALE RATS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 5, pp. 12–21, 2014, [Online]. Available: https://sid.ir/paper/58581/en

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