THE EFFECT OF EIGHT WEEK CONTINUOUS TRAINING ON EXPRESSION OF MICRORNAS29 MRNA, IN HEALTHY MALE RAT’S CARDIAC MUSCLE

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NEKOUEI A.; KORDI M.; CHOOBINEH S.; SOLEIMANI M.; SHAFIEE A.; HADIDI V.

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Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:6 Page(s): 113-120

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Title

THE EFFECT OF EIGHT WEEK CONTINUOUS TRAINING ON EXPRESSION OF MICRORNAS29 MRNA, IN HEALTHY MALE RAT’S CARDIAC MUSCLE

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Keywords

CONTINUOUS TRAININGQ1

MICRORNAS-29 FAMILYQ2

GENE EXPRESSIONQ2

CARDIAC MUSCLEQ1

Abstract

Background and aims: MiR29 family includes miR29a, miR29b and miR29c. Cell proliferation and differentiation, apoptosis and extracellular matrix regulation are some the cellular effects of miR29. The aim of this study was to evaluate the effect of eight weeks continues training on the expression of miR29 mRNA in the CARDIAC MUSCLE of healthy male rats.Methods: In this experimental study, 12 Male Wistar rats with were randomly divided into two groups in identical age and weight status: continues training and control groups (n= 6). Training protocol was prescribed 70-75% vo2max for 30 min in each session, 5 days/week, for 8 weeks. Autopsy and hearts tissue isolation did 24 hours after the last session of training. MiR29 expression was analyzed by quantitate RT-PCR and then calculated by 2-DDСТ method. Independent t-test was used to determine the significance of variables between study groups.Results: Results showed that there is a significant increase(72.6%), in GENE EXPRESSION miR29a,c in training group compared to control group (P=0.001), But miR29b GENE EXPRESSION showed reduction and it was not significant statistically (0.64%) (P=0.416).Conclusion: Based on the findings, it seems that continuous endurance training with 70-75% vo2max induces physiological hypertrophy in the heart of training group. Since this increase leads to a significant reduction in expression of collagen isoforms, it can be concluded that rising miR29a,c in physiological hypertrophy induced by endurance training directly regulates extracellular matrix and ventricular compliance.

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APA: Copy

NEKOUEI, A., KORDI, M., CHOOBINEH, S., SOLEIMANI, M., SHAFIEE, A., & HADIDI, V.. (2016). THE EFFECT OF EIGHT WEEK CONTINUOUS TRAINING ON EXPRESSION OF MICRORNAS29 MRNA, IN HEALTHY MALE RAT’S CARDIAC MUSCLE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(6), 113-120. SID. https://sid.ir/paper/58677/en

Vancouver: Copy

NEKOUEI A., KORDI M., CHOOBINEH S., SOLEIMANI M., SHAFIEE A., HADIDI V.. THE EFFECT OF EIGHT WEEK CONTINUOUS TRAINING ON EXPRESSION OF MICRORNAS29 MRNA, IN HEALTHY MALE RAT’S CARDIAC MUSCLE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(6):113-120. Available from: https://sid.ir/paper/58677/en

IEEE: Copy

A. NEKOUEI, M. KORDI, S. CHOOBINEH, M. SOLEIMANI, A. SHAFIEE, and V. HADIDI, “THE EFFECT OF EIGHT WEEK CONTINUOUS TRAINING ON EXPRESSION OF MICRORNAS29 MRNA, IN HEALTHY MALE RAT’S CARDIAC MUSCLE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 6, pp. 113–120, 2016, [Online]. Available: https://sid.ir/paper/58677/en

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