ANTITUMOR EFFECTS OF NITROGLYCERIN DRUG ON K562 CELLS

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AALAEI SH.; MOHAMMADZADEH M.; PAZHANG Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:6 Page(s): 83-91

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Title

ANTITUMOR EFFECTS OF NITROGLYCERIN DRUG ON K562 CELLS

Author(s)

AALAEI SH. | MOHAMMADZADEH M. | PAZHANG Y. | Issue Writer Certificate

Keywords

NITROGLYCERINEQ3

CYTOTOXICITYQ2

K562 CELLQ1

APOPTOSISQ3

Abstract

Background and aims: Leukemia is cancer of blood-forming tissues which derives from red and white blood progenitors cells. According to the needs of body, red and white blood cells usually grow, and divide with a controlled and regulated way, But in the leukemia, this process is disrupted, and it makes the growth of blood cells control aside. Nitroglycerin through changes to nitric oxide (NO), and increasing of NO cellular oxidative stress cause induces APOPTOSIS of cancer cells. This study was performed to survey the antitumor effects of nitroglycerin drug on K562 CELLs in vitro.Methods: First, The leukemia cells K562 category was cultured in RPMI 1640 with 10% of heat-inactivated fetal calf serum. Then, different concentrations of nitroglycerin drug were prepared, and their antitumor properties at 24, 48 and 72 hours after treatment were measured by MTT method. Then, the drugs IC50 were measured. In the next stage, in order to survey the apoptotic effect, electrophoresis and staining with Hoechst colors were used.Results: The results showed that the antitumor impacts of nitroglycerin dependently increase in a dose, and time. The IC50 of nitroglycerin was observed at 79 (mmol /ml). Also, the results of electrophoresis and staining showed that these drugs have the effect of APOPTOSIS.Conclusion: Based on the results, it can be inferred that inhibitory effect of nitroglycerin on K562 CELLs depends on time, and dose which the maximum inhibitory effect observed after 72 hours of treatments of the highest concentration. So, this drug may be effective in the prevention, and treatment of chronic leukemia.

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APA: Copy

AALAEI, SH., MOHAMMADZADEH, M., & PAZHANG, Y.. (2016). ANTITUMOR EFFECTS OF NITROGLYCERIN DRUG ON K562 CELLS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(6), 83-91. SID. https://sid.ir/paper/58680/en

Vancouver: Copy

AALAEI SH., MOHAMMADZADEH M., PAZHANG Y.. ANTITUMOR EFFECTS OF NITROGLYCERIN DRUG ON K562 CELLS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(6):83-91. Available from: https://sid.ir/paper/58680/en

IEEE: Copy

SH. AALAEI, M. MOHAMMADZADEH, and Y. PAZHANG, “ANTITUMOR EFFECTS OF NITROGLYCERIN DRUG ON K562 CELLS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 6, pp. 83–91, 2016, [Online]. Available: https://sid.ir/paper/58680/en

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