EFFICACY OF VITAMIN C AGAINST OXIDATIVE DAMAGES AND APOPTOSIS IN HEPATOCYTES OF MICE TREATED WITH PHENYLHYDRAZINE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KANBARA H.; SHAHROOZ R.; SHALIZAR JALALI A.; RAZI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahrekord University of Medical Sciences Year:2016 | Volume:17 | Issue:6 Page(s): 62-72

Download Full-Text

Persian Verion

View:

889

Download:

Cites:

Information Journal Paper

Title

EFFICACY OF VITAMIN C AGAINST OXIDATIVE DAMAGES AND APOPTOSIS IN HEPATOCYTES OF MICE TREATED WITH PHENYLHYDRAZINE

Author(s)

KANBARA H. | SHAHROOZ R. | SHALIZAR JALALI A. | RAZI M. | Issue Writer Certificate

Keywords

PHENYLHYDRAZINEQ1

VITAMIN CQ2

APOPTOSISQ1

LIVERQ2

MOUSEQ2

Abstract

Background and aims: PHENYLHYDRAZINE (PHZ) as a well-known hemolytic agent can induce a variety of adverse effects including hepatotoxicity. The main aim of the present study was to examine the possible efficacy of VITAMIN C against PHZ-induced oxidative damages and APOPTOSIS in MOUSE LIVER.Methods: In this randomized controlled experimental study, 32 adult male mice were assigned to four groups of eight mice each. Two groups of mice received PHZ at a dose of 60 mg/kg per 48 hours intraperitoneally for 35 days. VITAMIN C was administered to one of these groups at a dose of 250 mg/kg per day intraperitoneally four hours before PHZ injection. A vehicle-treated control group and a VITAMIN C-only treated group were also included. Serum and hepatic samples were collected 24 hours after the last treatment and subjected to biochemical and histomorphometric and histochemical examinations, respectively. The data were analyzed by one-way analysis of variance followed by Duncan test for post hoc comparisons.Results: PHZ treatment caused a significant elevation (P<0.05) in serum concentrations of aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and malondealdehyde and decreased serum level of total antioxidant capacity, superoxide dismutase and albumin. Moreover, PHZ significantly increased APOPTOSIS and diameters of hepatocytes and their nuclei as well as number of Kupffer cells.Conclusion: VITAMIN C can modulate PHZ-induced oxidative injuries and APOPTOSIS in MOUSE LIVER due to its antioxidant activities.

Cites

No record.

References

No record.

Cite

APA: Copy

KANBARA, H., SHAHROOZ, R., SHALIZAR JALALI, A., & RAZI, M.. (2016). EFFICACY OF VITAMIN C AGAINST OXIDATIVE DAMAGES AND APOPTOSIS IN HEPATOCYTES OF MICE TREATED WITH PHENYLHYDRAZINE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 17(6), 62-72. SID. https://sid.ir/paper/58685/en

Vancouver: Copy

KANBARA H., SHAHROOZ R., SHALIZAR JALALI A., RAZI M.. EFFICACY OF VITAMIN C AGAINST OXIDATIVE DAMAGES AND APOPTOSIS IN HEPATOCYTES OF MICE TREATED WITH PHENYLHYDRAZINE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;17(6):62-72. Available from: https://sid.ir/paper/58685/en

IEEE: Copy

H. KANBARA, R. SHAHROOZ, A. SHALIZAR JALALI, and M. RAZI, “EFFICACY OF VITAMIN C AGAINST OXIDATIVE DAMAGES AND APOPTOSIS IN HEPATOCYTES OF MICE TREATED WITH PHENYLHYDRAZINE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 6, pp. 62–72, 2016, [Online]. Available: https://sid.ir/paper/58685/en

Related Journal Papers