THE STUDY OF THRESHOLD OF PAIN SENSATION IN RATS BORN FROM NORMAL MOTHERS AND MOTHERS WITH METABOLIC ACIDOSIS

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NAZARI M.; KHATAMSAZ S.; SADEGHI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Shahrekord University of Medical Sciences Year:2014 | Volume:16 | Issue:4 Page(s): 46-53

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Title

THE STUDY OF THRESHOLD OF PAIN SENSATION IN RATS BORN FROM NORMAL MOTHERS AND MOTHERS WITH METABOLIC ACIDOSIS

Author(s)

NAZARI M. | KHATAMSAZ S. | SADEGHI H. | Issue Writer Certificate

Keywords

SENSORY THRESHOLDQ2

PAIN SCOREQ2

METABOLIC ACIDOSISQ3

AMMONIUM CHLORIDEQ2

Abstract

Background and aims: METABOLIC ACIDOSIS is one of the most important diseases that affects nervous system. The aim of this study was to investigate the potential variations in sensory pain threshold in children born to mothers with METABOLIC ACIDOSIS compared with children born to healthy mothers.Methods: In this experimental study, 50 healthy female rats were randomly divided into five equal groups; control with no treatment, control with minimum dose, control with moderate dose, acidosis with minimum dose, and acidosis with moderate dose. To induce acidosis, AMMONIUM CHLORIDE was used instead of drinking water. Also, sodium chloride was administered for control groups. All animals were conceived by natural mating.20 days prior to and till the completion of pregnancy, the rats received the solutions. For the groups with minimum and moderate doses, the solutions of interest at respectively 0.15 and 0.3 mol were used. Tests of the pain due to formalin were conducted on adult male children. PAIN SCORE were registered in three acute, interphase, and chronic stages and compared. For intergroup statistical analysis of the data, one-way ANOVA and Turkey’s post hoc test were used at significance level of P£0.05. Normality and homogeneity of pain variance were investigated and compared in the groups. So, the conditions of running parametric tests applied.Results: Results indicated a significant increase in pain in acute and chronic stages of formalin test in male children born to acidosis mothers (P£0.05). PAIN SCOREs were not significantly different between acidosis and control groups in interphase stage (P£0.05).Conclusion: Results indicated that the effects by METABOLIC ACIDOSIS caused decrease in sensory pain threshold in the children born to METABOLIC ACIDOSIS mothers and increase in their pain.Therefore, through preventing development of METABOLIC ACIDOSIS, decrease in sensory pain threshold could be prevented in their children.

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APA: Copy

NAZARI, M., KHATAMSAZ, S., & SADEGHI, H.. (2014). THE STUDY OF THRESHOLD OF PAIN SENSATION IN RATS BORN FROM NORMAL MOTHERS AND MOTHERS WITH METABOLIC ACIDOSIS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 16(4), 46-53. SID. https://sid.ir/paper/58771/en

Vancouver: Copy

NAZARI M., KHATAMSAZ S., SADEGHI H.. THE STUDY OF THRESHOLD OF PAIN SENSATION IN RATS BORN FROM NORMAL MOTHERS AND MOTHERS WITH METABOLIC ACIDOSIS. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;16(4):46-53. Available from: https://sid.ir/paper/58771/en

IEEE: Copy

M. NAZARI, S. KHATAMSAZ, and H. SADEGHI, “THE STUDY OF THRESHOLD OF PAIN SENSATION IN RATS BORN FROM NORMAL MOTHERS AND MOTHERS WITH METABOLIC ACIDOSIS,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 4, pp. 46–53, 2014, [Online]. Available: https://sid.ir/paper/58771/en

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